IFNW1 and IFNAR1

Number of citations of the paper that reports this interaction (PubMedID 1834641)
0

Data Source:
HPRD (in vivo)

		IFNW1	IFNAR1
Description		interferon omega 1	interferon alpha and beta receptor subunit 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Receptor Complex	Lysosome Endosome Late Endosome Plasma Membrane Membrane Receptor Complex
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Type I Interferon Receptor Binding Protein Binding	Interferon Receptor Activity Type I Interferon Receptor Activity Protein Binding JAK Pathway Signal Transduction Adaptor Activity Cytokine Binding Type I Interferon Binding
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response B Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Defense Response Humoral Immune Response Response To Virus Response To Exogenous DsRNA Defense Response To Virus Regulation Of Cell Cycle Type I Interferon-mediated Signaling Pathway Cellular Response To Virus	Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Positive Regulation Of Metabolic Process Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Cellular Response To Interferon-beta Regulation Of Receptor Signaling Pathway Via JAK-STAT Type I Interferon-mediated Signaling Pathway Cellular Response To Virus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Cellular Respiration
Pathways			Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling Potential therapeutics for SARS SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses
Drugs			Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Interferon alfa Human interferon omega-1 Peginterferon beta-1a Anifrolumab Human interferon beta Ropeginterferon alfa-2b
Diseases
GWAS			Blood protein levels ( 30072576) Crohn's disease ( 23128233) Psoriasis ( 25903422)
Interacting Genes		4 interacting genes: APP IFNAR1 S100A6 S100P	26 interacting genes: BRCC3 CRKL FBXW11 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LAPTM4B LCK LRPAP1 MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70
Entrez ID		3467	3454
HPRD ID		00944	00126
Ensembl ID		ENSG00000177047	ENSG00000142166
Uniprot IDs		P05000	A0A8V8TQK8 A0A994J6F6 P17181
PDB IDs		3SE4	3S98 3SE3 3SE4 4PO6 8Y31
Enriched GO Terms of Interacting Partners?		Transition Metal Ion Binding Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Protein Homodimerization Activity Lipoprotein Particle Regulation Of Protein Localization To Nucleus Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Axonogenesis Regulation Of Generation Of Precursor Metabolites And Energy Type I Interferon Receptor Activity Type I Interferon Binding JAK Pathway Signal Transduction Adaptor Activity Interferon Receptor Activity Calcium-dependent Protein Binding Receptor Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Neuron Projection Morphogenesis Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Cell Projection Morphogenesis Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Cellular Response To Interferon-alpha	Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Signal Transduction Type I Interferon-mediated Signaling Pathway Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Immune System Process T Cell Receptor Signaling Pathway Regulation Of Immune Response Cytokine Receptor Binding Regulation Of Hemopoiesis T Cell Activation Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Adhesion Type I Interferon Receptor Binding Regulation Of Cytokine Production Cellular Response To Virus Positive Regulation Of Signal Transduction Protein Modification Process Natural Killer Cell Activation Involved In Immune Response Antigen Receptor-mediated Signaling Pathway Leukocyte Activation Involved In Immune Response Positive Regulation Of Intracellular Signal Transduction Response To Exogenous DsRNA Regulation Of Intracellular Signal Transduction Cell Activation Involved In Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Developmental Process Leukocyte Activation Response To DsRNA Positive Regulation Of Immune System Process B Cell Activation Regulation Of Multicellular Organismal Process Immune System Process Lymphocyte Activation Natural Killer Cell Activation Cell Activation Phosphate-containing Compound Metabolic Process Negative Regulation Of Cytokine Production Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Gene Expression
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