ADGRE2 and ELOVL7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ADGRE2	ELOVL7
Description		adhesion G protein-coupled receptor E2	ELOVL fatty acid elongase 7
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GO Annotations	Cellular Component	Plasma Membrane Membrane Leading Edge Membrane Ruffle Membrane Cell Projection	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding Protein Binding Chondroitin Sulfate Binding	Protein Binding Fatty Acid Elongase Activity Transferase Activity
	Biological Process	Immune System Process Inflammatory Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell Migration Regulation Of Mast Cell Degranulation Granulocyte Chemotaxis	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process
Pathways		Class B/2 (Secretin family receptors)	Synthesis of very long-chain fatty acyl-CoAs
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243)	Age at first sexual intercourse ( 34211149) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cortical surface area ( 32963231) Cortical surface area (MOSTest) ( 32665545) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Mean platelet volume ( 32888494 27863252) Multiple system atrophy ( 27629089) Parkinson's disease ( 32201043 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Subcortical volume (MOSTest) ( 32665545) Working memory ( 31598132)
Interacting Genes		26 interacting genes: AQP6 BIK CCDC107 CD79A CREB3L1 ELOVL4 ELOVL7 ERGIC3 FAM209A FAM210B FCER1G FKBP7 GPR42 HSD17B13 KIR2DL3 LMNA MARCHF6 MMGT1 MTERF3 MTIF3 SAR1A SLC18A1 SLC61A1 SLC7A14 TLCD4 TMEM80	12 interacting genes: ADGRE2 DTNBP1 EMP3 LRCH4 RTP2 SERF1A SERF1B SLC41A1 SYNJ2BP TMEM14C UBE2J2 VAMP1
Entrez ID		30817	79993
HPRD ID		07308	18700
Ensembl ID		ENSG00000127507	ENSG00000164181
Uniprot IDs		A0JNV7 B4DWB8 Q9UHX3	A1L3X0 D6RHD0
PDB IDs		2BO2 2BOU 2BOX	6Y7F
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid Endoplasmic Reticulum Membrane Serotonin Transport Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Long-chain Fatty-acyl-CoA Biosynthetic Process Long-chain Fatty-acyl-CoA Metabolic Process Fatty-acyl-CoA Biosynthetic Process
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