ZDHHC21 and TRIM59

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZDHHC21	TRIM59
Description		zDHHC palmitoyltransferase 21	tripartite motif containing 59
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intraciliary Transport Particle B
	Molecular Function	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Hair Follicle Development Regulation Of Vascular Associated Smooth Muscle Contraction Protein Targeting To Membrane Peptidyl-L-cysteine S-palmitoylation Nitric Oxide Metabolic Process Sebaceous Gland Development Adrenergic Receptor Signaling Pathway Regulation Of Establishment Of Endothelial Barrier Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell	Protein Ubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Host-mediated Suppression Of Symbiont Invasion
Pathways		eNOS activation Extra-nuclear estrogen signaling
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697) Hypothyroidism ( 22493691) Metabolite levels ( 23823483) Neuritic plaque ( 31497858) Schizophrenia ( 33169155) Visceral adipose tissue adjusted for BMI ( 22589738)	Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Bipolar disorder ( 31043756) Eosinophil percentage of white cells ( 32888494) Intrinsic epigenetic age acceleration ( 29374233) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		12 interacting genes: AQP6 CHODL CREB3 ELOVL4 ERGIC3 FAM210B MTERF3 MUC1 PGRMC2 RNASEK TMEM167B TRIM59	29 interacting genes: ANKRD33 BLZF1 CCDC33 CDK5 CLDN4 ECSIT EIF2B1 ESR1 ESR2 KEAP1 KRTAP13-3 MACROH2A1 MEI4 MRPL12 NECAB2 NRM PIN1 PKNOX1 PLLP RASSF3 RHOU SEC22A SNAP47 SYVN1 UBE2J2 UBE2W VTI1B ZDHHC21 ZDHHC22
Entrez ID		340481	286827
HPRD ID		15716	15568
Ensembl ID		ENSG00000175893	ENSG00000213186
Uniprot IDs		Q8IVQ6	Q8IWR1
PDB IDs
Enriched GO Terms of Interacting Partners?			Nuclear Estrogen Receptor Activity SNAP Receptor Activity Negative Regulation Of Response To Oxidative Stress
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