ZDHHC21 and ELOVL4

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ZDHHC21	ELOVL4
Name		zDHHC palmitoyltransferase 21	ELOVL fatty acid elongase 4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity	Protein Binding G Protein-coupled Photoreceptor Activity Fatty Acid Elongase Activity Transferase Activity
	Biological Process	Hair Follicle Development Regulation Of Vascular Associated Smooth Muscle Contraction Protein Targeting To Membrane Peptidyl-L-cysteine S-palmitoylation Nitric Oxide Metabolic Process Sebaceous Gland Development Adrenergic Receptor Signaling Pathway Regulation Of Establishment Of Endothelial Barrier Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Detection Of Visible Light Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process
Pathways		eNOS activation Extra-nuclear estrogen signaling	Synthesis of very long-chain fatty acyl-CoAs
Drugs		None	Omega-3-carboxylic acids
Diseases		None	Stargardt disease (STGD); Fundus flavimaculatus
GWAS		Age at first sexual intercourse ( 34211149 ) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697 ) Hypothyroidism ( 22493691 ) Metabolite levels ( 23823483 ) Neuritic plaque ( 31497858 ) Schizophrenia ( 33169155 ) Visceral adipose tissue adjusted for BMI ( 22589738 )	Aging ( 22773346 ) Body mass index ( 23669352 ) Chronic obstructive pulmonary disease ( 28166215 ) Daytime sleep phenotypes ( 27126917 ) Hip circumference adjusted for BMI ( 34021172 ) Macular thickness ( 30535121 ) Partial epilepsies ( 20522523 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		12 interacting genes: AQP6 CHODL CREB3 ELOVL4 ERGIC3 FAM210B MTERF3 MUC1 PGRMC2 RNASEK TMEM167B TRIM59	106 interacting genes: ADGRE2 ANKRD46 APOL2 APOL3 ARLN ATP13A1 BCL2L1 BET1 BIK BNIP1 BNIP3 BTN2A2 C1GALT1 CCDC167 CCL4L2 CD70 CDIPT CLCA4 CLDND2 CMTM3 CMTM5 CMTM7 COL4A5 CYB5R3 CYP4F2 EMC6 ERG28 FA2H FAM177A1 FAM3C FAXDC2 FDFT1 FKBP8 FXYD6 GIMAP1 GIMAP5 GOSR2 GPR37L1 GYPA HMOX1 HMOX2 HSD3B7 IER3IP1 INSIG2 ITGAM JAGN1 LEPROTL1 LHFPL5 LPAR3 LY6D MALL MMP14 NINJ2 ORMDL2 ORMDL3 PEX16 PKMYT1 PLLP PLN PLP1 PTPN1 RAB18 RTP2 SEC22A SEC22B SERF1A SERF1B SERP2 SFT2D2 SLC30A3 SLC30A8 SMCO4 SMIM1 SNORC STX3 STX8 SYNDIG1 TECR TF TMEM11 TMEM128 TMEM19 TMEM203 TMEM218 TMEM222 TMEM242 TMEM243 TMEM254 TMEM42 TMEM44 TRARG1 TREX1 TSNARE1 UBE2J1 UBIAD1 UNC50 VAMP1 VAMP3 VAMP4 VAMP5 VAPB VMA12 YIF1A YIPF6 ZDHHC21 ZFPL1
Entrez ID		340481	6785
HPRD ID		15716	05697
Ensembl ID		ENSG00000175893	ENSG00000118402
Uniprot IDs		Q8IVQ6	Q9GZR5
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Endomembrane System Membrane Fusion Organelle Fusion Organelle Membrane Fusion Vesicle-mediated Transport Golgi Vesicle Transport Establishment Of Protein Localization Vesicle Fusion Protein Binding Membrane Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle Organization Cellular Localization Sterol Biosynthetic Process Establishment Of Protein Localization To Membrane Golgi Membrane Steroid Biosynthetic Process Mitochondrial Membrane Membrane Docking Structural Constituent Of Myelin Sheath Intracellular Transport Endoplasmic Reticulum Organization Heme Oxidation Heme Oxygenase (decyclizing) Activity Transport Vesicle SNARE Complex Assembly Lipid Biosynthetic Process Organelle Localization By Membrane Tethering Sterol Metabolic Process Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Golgi Apparatus Insulin Metabolic Process Inorganic Ion Homeostasis Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Establishment Of Protein Localization To Plasma Membrane Establishment Of Localization In Cell Intracellular Protein Localization Intracellular Chemical Homeostasis Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Menaquinone Metabolic Process Negative Regulation Of Sphingolipid Biosynthetic Process Vesicle Docking Steroid Metabolic Process