MSL1 and KAT8

Number of citations of the paper that reports this interaction (PMID 16227571)
82

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down)

		MSL1	KAT8
Gene Name		male-specific lethal 1 homolog (Drosophila)	K(lysine) acetyltransferase 8
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm MSL Complex	Histone Acetyltransferase Complex Kinetochore Nucleus Nucleoplasm Nuclear Membrane MLL1 Complex MSL Complex
	Molecular Function		Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Acetyltransferase Activity Enzyme Binding Methylated Histone Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Metal Ion Binding Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Chromatin Organization Histone H4-K16 Acetylation	Chromatin Organization Transcription, DNA-templated Regulation Of Autophagy Histone Acetylation Myeloid Cell Differentiation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: CRKL FCHSD2 HIST2H2BE HORMAD1 KAT8 KPNB1 MORF4L1 MRGBP NUPR1 PAF1 PPM1G RAN RNF20 RNF40 SMARCC1 SNW1 UBE2D3	11 interactors: ATM BAZ2A FOXP3 HIST1H4A KANSL1 KMT2A MSL1 MSL3 PAF1 RNF2 TP53
Entrez ID		339287	84148
HPRD ID		19425	11381
Ensembl ID		ENSG00000188895	ENSG00000103510
Uniprot IDs		B3KWR7 J3KSZ8 Q68DK7	Q9H7Z6
PDB IDs		4B7Y 4B86 4DNC	2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Organization Protein Monoubiquitination Histone H2B Ubiquitination Chromatin Modification Histone Monoubiquitination Histone Ubiquitination Histone Modification Organelle Organization Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Protein Acetylation Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Import Intracellular Transport Of Virus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Histone Methylation Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Protein Ubiquitination RNA Metabolic Process Cellular Protein Modification Process Regulation Of Histone Methylation Histone H4 Acetylation Protein Modification By Small Protein Conjugation Regulation Of Homologous Chromosome Segregation Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Histone Modification Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Meiotic Recombination Checkpoint Positive Regulation Of Vitamin D Receptor Signaling Pathway	Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Histone H4-K16 Acetylation Organelle Organization Histone H4 Acetylation Peptidyl-lysine Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Protein Modification Process Peptidyl-amino Acid Modification Regulation Of Chromosome Organization DNA Methylation Negative Regulation Of Transcription, DNA-templated Anterior/posterior Pattern Specification Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Histone Modification Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Proliferation DNA Modification Replicative Senescence Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Silencing At RDNA Transcription, DNA-templated Negative Regulation Of Immune System Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Histone Modification RNA Biosynthetic Process Regulation Of Gene Expression Chromatin Assembly Cellular Nitrogen Compound Metabolic Process Histone Monoubiquitination Chromatin Assembly Or Disassembly Pattern Specification Process DNA Metabolic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Chromatin Remodeling DNA Packaging
Tagcloud ?		alters aspect comprise correlating cryptic exonic h2b h2bk123ub1 h3k36me3 htb intragenic intron intronic introns k123r lea1 lethality marks monoubiquitylation orfs packaging postulated saccharomyces snrnp splicing talk transcribed trimethylation u2	acetylated acetylation acetyltransferase acetyltransferases alter broad compaction compensation decompact dosage embryonic enhancers ep300 escs flies h3k27 h3k4me1 h4 h4k16 h4k16ac histone interest marked marks nucleosomes peaks start surprisingly tails
Tagcloud (Difference) ?		alters aspect comprise correlating cryptic exonic h2b h2bk123ub1 h3k36me3 htb intragenic intron intronic introns k123r lea1 lethality monoubiquitylation orfs packaging postulated saccharomyces snrnp splicing talk transcribed trimethylation u2	acetylated acetylation acetyltransferase acetyltransferases alter broad compaction compensation decompact dosage embryonic enhancers ep300 escs flies h3k27 h3k4me1 h4 h4k16 h4k16ac histone interest marked nucleosomes peaks start surprisingly tails
Tagcloud (Intersection) ?		marks