KAT8 and MSL3

Number of citations of the paper that reports this interaction (PMID 20479123)
49

Data Source:
BioGRID (affinity chromatography technology, pull down)

		KAT8	MSL3
Gene Name		K(lysine) acetyltransferase 8	male-specific lethal 3 homolog (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Kinetochore Nucleus Nucleoplasm Nuclear Membrane MLL1 Complex MSL Complex	Nucleus Nucleoplasm MSL Complex
	Molecular Function	Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Acetyltransferase Activity Enzyme Binding Methylated Histone Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Metal Ion Binding Histone Acetyltransferase Activity (H4-K16 Specific)	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Methylated Histone Binding
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Autophagy Histone Acetylation Myeloid Cell Differentiation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated	Chromatin Organization Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Histone H4-K16 Acetylation
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ATM BAZ2A FOXP3 HIST1H4A KANSL1 KMT2A MSL1 MSL3 PAF1 RNF2 TP53	8 interactors: APP CDK6 HIST1H3A HIST1H4A HIST3H3 HIST4H4 KAT8 PAF1
Entrez ID		84148	10943
HPRD ID		11381	05344
Ensembl ID		ENSG00000103510	ENSG00000005302
Uniprot IDs		Q9H7Z6	B7Z227 Q8N5Y2
PDB IDs		2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC	2Y0N 3OA6 3OB9
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Histone H4-K16 Acetylation Organelle Organization Histone H4 Acetylation Peptidyl-lysine Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Protein Modification Process Peptidyl-amino Acid Modification Regulation Of Chromosome Organization DNA Methylation Negative Regulation Of Transcription, DNA-templated Anterior/posterior Pattern Specification Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Histone Modification Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Proliferation DNA Modification Replicative Senescence Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Silencing At RDNA Transcription, DNA-templated Negative Regulation Of Immune System Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Histone Modification RNA Biosynthetic Process Regulation Of Gene Expression Chromatin Assembly Cellular Nitrogen Compound Metabolic Process Histone Monoubiquitination Chromatin Assembly Or Disassembly Pattern Specification Process DNA Metabolic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Chromatin Remodeling DNA Packaging	DNA Replication-dependent Nucleosome Assembly DNA Methylation On Cytosine Negative Regulation Of Myeloid Cell Differentiation Chromatin Silencing At RDNA Chromatin Silencing Chromosome Organization Regulation Of Myeloid Cell Differentiation Histone H4-K20 Demethylation DNA Methylation Negative Regulation Of Megakaryocyte Differentiation Chromatin Organization Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance DNA Modification Negative Regulation Of Immune System Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Gene Silencing Histone Modification Nucleosome Assembly Chromatin Assembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Nucleosome Organization Negative Regulation Of RNA Biosynthetic Process Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Regulation Of Megakaryocyte Differentiation DNA Packaging Negative Regulation Of Gene Expression Chromatin Modification Negative Regulation Of Biosynthetic Process Homeostatic Process CENP-A Containing Nucleosome Assembly Regulation Of Gene Expression, Epigenetic MRNA Polyadenylation Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange DNA Replication-independent Nucleosome Assembly Histone Lysine Demethylation Regulation Of Cell Differentiation Histone Demethylation RNA Polyadenylation Nucleobase-containing Compound Metabolic Process Protein Demethylation DNA Conformation Change Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression
Tagcloud ?		acetylated acetylation acetyltransferase acetyltransferases alter broad compaction compensation decompact dosage embryonic enhancers ep300 escs flies h3k27 h3k4me1 h4 h4k16 h4k16ac histone interest marked marks nucleosomes peaks start surprisingly tails	achieve analyze chip chromodomain chromodomains compensation counterparts disruption dosage drosophila entry flanking h3k36me3 lethal marked melanogaster mutants nucleosomal nucleosomes preferential respective retain similarly spread spreading targeting trimethylation upregulates
Tagcloud (Difference) ?		acetylated acetylation acetyltransferase acetyltransferases alter broad compaction decompact embryonic enhancers ep300 escs flies h3k27 h3k4me1 h4 h4k16 h4k16ac histone interest marks peaks start surprisingly tails	achieve analyze chip chromodomain chromodomains counterparts disruption drosophila entry flanking h3k36me3 lethal melanogaster mutants nucleosomal preferential respective retain similarly spread spreading targeting trimethylation upregulates
Tagcloud (Intersection) ?		compensation dosage marked nucleosomes