TMEM119 and CERS4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM119	CERS4
Description		transmembrane protein 119	ceramide synthase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function		DNA Binding Protein Binding Transferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Ossification Osteoblast Differentiation Endochondral Ossification Spermatogenesis Positive Regulation Of Gene Expression Negative Regulation Of Myotube Differentiation Cell Differentiation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Biomineral Tissue Development Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Bone Resorption Spermatid Differentiation Positive Regulation Of Bone Development	Lipid Metabolic Process Sphingolipid Metabolic Process Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process
Pathways			Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Heel bone mineral density ( 30598549) Intraocular pressure ( 29235454 29617998 30054594) Optic disc size ( 31809533) Refractive error ( 32231278)	Macular telangiectasia type 2 ( 33654266) Mean reticulocyte volume ( 32888494) Metabolite levels ( 31628463) Red cell distribution width ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469) Thyroid stimulating hormone levels ( 30367059 32769997) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)
Interacting Genes		7 interacting genes: AQP6 CERS4 ODF4 SLC10A1 SLC10A6 SLC71A2 TSHR	47 interacting genes: - C1QL4 CCL4L2 CLEC1A COL4A5 CTXN3 CXCL16 CYB5R3 EMD FATE1 FCER1G FXYD6 FXYD6-FXYD2 GPR151 IER3IP1 IGFBP5 ITGAM JAGN1 LHFPL5 MS4A1 NAT8 NEU1 PLP2 PNLIPRP1 PTPN9 SCAMP5 SCD SERF1A SERF1B SERP2 SLC13A4 SLC29A2 SLC35A1 SLC35F6 SLC7A1 SMIM11 STX7 STX8 TEX264 TMEM119 TMEM176A TMEM254 TMEM72 TOMM6 TSPO2 UPK1B VAMP2
Entrez ID		338773	79603
HPRD ID		11260	13962
Ensembl ID		ENSG00000183160	ENSG00000090661
Uniprot IDs		Q4V9L6	Q53HF9 Q9HA82
PDB IDs
Enriched GO Terms of Interacting Partners?		Bile Acid:sodium Symporter Activity Bile Acid And Bile Salt Transport PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Transmembrane Transport Symporter Activity Cellular Response To Thyrotropin-releasing Hormone Thyroid-stimulating Hormone Receptor Activity Thyroid-stimulating Hormone Signaling Pathway Response To Thyrotropin-releasing Hormone Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Monocarboxylic Acid Transport Membrane Cellular Response To Glycoprotein Organic Hydroxy Compound Transport Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Sodium Ion Transport Sphingosine N-acyltransferase Activity Monoatomic Anion Channel Activity Renal Water Transport Ammonium Transmembrane Transport Ammonium Channel Activity Bile Acid Transmembrane Transporter Activity Basolateral Plasma Membrane Protein-hormone Receptor Activity Monoatomic Ion Transport Carboxylic Acid Transport Organic Acid Transport Water Channel Activity Carbon Dioxide Transport Lipid Transport Organic Anion Transport Water Transport One-carbon Compound Transport	Membrane Amyloid Fibril Formation Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of Exocytosis SNAP Receptor Activity Chloride Channel Inhibitor Activity Membrane Organization Positive Regulation Of Regulated Secretory Pathway SNARE Complex Syntaxin Binding Regulation Of Regulated Secretory Pathway Regulation Of Cellular Localization Regulation Of Protein Localization SNARE Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?