KRTAP6-1 and P4HA3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP6-1	P4HA3
Description		keratin associated protein 6-1	prolyl 4-hydroxylase subunit alpha 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Protein Binding	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Keratinization	Collagen Fibril Organization
Pathways		Keratinization	Collagen biosynthesis and modifying enzymes
Drugs
Diseases
GWAS			Hippocampal atrophy ( 25625606)
Interacting Genes		91 interacting genes: ANAPC11 APOBEC1 ARID5A BAHD1 BHLHE40 C11orf16 CAMK2A CAMK2G CATSPER1 CCDC120 CCDC187 CCDC24 CDA CELF5 CREB5 CRYAB CYSRT1 DAZAP2 DTX2 EFEMP1 EVX2 FCHO1 GLIS2 GLIS3 GNE GPS2 GRN HELT HEY2 HHEX HOXA1 HOXC8 ITIH6 KPRP KRTAP11-1 KRTAP12-1 KRTAP12-3 KRTAP26-1 KRTAP3-1 KRTAP4-5 KRTAP6-2 KRTAP6-3 LONRF1 MAGED1 MAPK1IP1L MED25 MEIS2 MGAT5B MYOZ3 NAF1 NOTO NTAQ1 OLIG3 OSR2 OTX1 P4HA3 PATZ1 PDIA2 PITX1 PITX2 PLSCR3 PLSCR4 POU1F1 POU4F2 PRR13 PRR35 RBPMS2 RHOXF2 SMARCC1 SMN1 SMN2 SNRPB SPANXB1 TCF7L2 TEKT3 TENT5B TFAP2D TLX3 TNIP1 TOLLIP TRAPPC14 TRIP13 UNC5CL VAC14 VENTX VGLL3 VPS37C ZBTB32 ZC3H10 ZIC1 ZNF414	49 interacting genes: ACOT8 ADRA2C ANAPC11 ATN1 B9D2 BAG4 BLOC1S2 C1QTNF2 CERCAM CKMT2 CLPP CT55 CTAG1A CTAG1B CTNNBIP1 DTNBP1 FAM136A FIRRM GGA3 GPSM3 HGS KRTAP19-5 KRTAP6-1 KRTAP8-1 LRP2BP MAGEA2 MAGEA2B MAGEC2 MCCD1 MEOX2 MSRA NDN NICN1 NUTM1 OIP5 P4HB PROP1 PSMB4 RBFOX1 RUSC1 SCARA5 SERTAD1 SERTAD3 STMN3 TLE5 TOX2 VPS37C WDR62 ZC3H12A
Entrez ID		337966	283208
HPRD ID		11218	16413
Ensembl ID		ENSG00000184724	ENSG00000149380
Uniprot IDs		Q3LI64	Q7Z4N8
PDB IDs
Enriched GO Terms of Interacting Partners?		Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleus Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Intermediate Filament Regulation Of Gene Expression DNA Binding Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Pattern Specification Process Keratin Filament Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Identical Protein Binding Transcription Regulator Complex Myoblast Fate Commitment Negative Regulation Of Macromolecule Metabolic Process Regionalization SMN-Sm Protein Complex Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Anterior/posterior Pattern Specification Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Atrioventricular Valve Development Embryonic Morphogenesis	Protein Binding Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Acetylation Gamma-tubulin Binding
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