KRTAP6-1 and PDIA2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP6-1	PDIA2
Description		keratin associated protein 6-1	protein disulfide isomerase family A member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Protein Binding	Protein Disulfide Isomerase Activity Steroid Binding Protein Binding Lipid Binding Protein-disulfide Reductase Activity Disulfide Oxidoreductase Activity Isomerase Activity
	Biological Process	Keratinization	Protein Folding Protein Retention In ER Lumen Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Platelet Aggregation
Pathways		Keratinization	Developmental Lineage of Pancreatic Acinar Cells
Drugs
Diseases
GWAS			Body mass index ( 26426971) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		91 interacting genes: ANAPC11 APOBEC1 ARID5A BAHD1 BHLHE40 C11orf16 CAMK2A CAMK2G CATSPER1 CCDC120 CCDC187 CCDC24 CDA CELF5 CREB5 CRYAB CYSRT1 DAZAP2 DTX2 EFEMP1 EVX2 FCHO1 GLIS2 GLIS3 GNE GPS2 GRN HELT HEY2 HHEX HOXA1 HOXC8 ITIH6 KPRP KRTAP11-1 KRTAP12-1 KRTAP12-3 KRTAP26-1 KRTAP3-1 KRTAP4-5 KRTAP6-2 KRTAP6-3 LONRF1 MAGED1 MAPK1IP1L MED25 MEIS2 MGAT5B MYOZ3 NAF1 NOTO NTAQ1 OLIG3 OSR2 OTX1 P4HA3 PATZ1 PDIA2 PITX1 PITX2 PLSCR3 PLSCR4 POU1F1 POU4F2 PRR13 PRR35 RBPMS2 RHOXF2 SMARCC1 SMN1 SMN2 SNRPB SPANXB1 TCF7L2 TEKT3 TENT5B TFAP2D TLX3 TNIP1 TOLLIP TRAPPC14 TRIP13 UNC5CL VAC14 VENTX VGLL3 VPS37C ZBTB32 ZC3H10 ZIC1 ZNF414	12 interacting genes: ACTB CALR COL2A1 CUL3 GAPDH KRTAP12-1 KRTAP6-1 MAPT P4HTM PPARG SNCA SST
Entrez ID		337966	64714
HPRD ID		11218	07617
Ensembl ID		ENSG00000184724	ENSG00000185615
Uniprot IDs		Q3LI64	Q13087
PDB IDs
Enriched GO Terms of Interacting Partners?		Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleus Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Intermediate Filament Regulation Of Gene Expression DNA Binding Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Pattern Specification Process Keratin Filament Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Identical Protein Binding Transcription Regulator Complex Myoblast Fate Commitment Negative Regulation Of Macromolecule Metabolic Process Regionalization SMN-Sm Protein Complex Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Anterior/posterior Pattern Specification Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Atrioventricular Valve Development Embryonic Morphogenesis	Regulation Of Norepinephrine Uptake Transporter Regulator Activity Identical Protein Binding Negative Regulation Of Mitochondrial Fission Regulation Of Organelle Organization Regulation Of Multicellular Organismal Process Regulation Of Synaptic Vesicle Recycling Peptide Binding Regulation Of Protein Stability Hormone-mediated Signaling Pathway Regulation Of Mitochondrial Fission Microglial Cell Activation Amyloid Fibril Formation Leukocyte Activation Involved In Inflammatory Response Cytosol Cytoskeleton Organization Cellular Response To Oxidative Stress Kinesin Binding Tau Protein Binding Regulation Of Chromosome Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Postsynapse Negative Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process Microtubule Binding Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Biological Quality Cellular Response To Chemical Stress Protein Destabilization Cellular Response To Growth Factor Stimulus Macrophage Activation Regulation Of Microtubule Polymerization Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Xenobiotic Stimulus Homeostatic Process Regulation Of Endocytosis Response To Metal Ion Response To Growth Factor Apoptotic Signaling Pathway Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Neurofibrillary Tangle Assembly
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