CLTB and MYO6

Number of citations of the paper that reports this interaction (PubMedID 31672988)
69

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CLTB	MYO6
Description		clathrin light chain B	myosin VI
Image		No pdb structure
GO Annotations	Cellular Component	Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin Coat Clathrin Vesicle Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Clathrin-coated Endocytic Vesicle Ciliary Membrane Presynaptic Endocytic Zone Membrane	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Endosome Autophagosome Golgi Apparatus Cytosol Actin Filament Plasma Membrane Microvillus Clathrin-coated Pit Cell Cortex Actin Cytoskeleton Membrane Myosin Complex Unconventional Myosin Complex Clathrin-coated Vesicle Endocytic Vesicle Filopodium Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Filamentous Actin Nuclear Membrane Ruffle Membrane Protein-containing Complex Cell Projection Apical Part Of Cell Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Clathrin Heavy Chain Binding Peptide Binding	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity
	Biological Process	Intracellular Protein Transport Vesicle-mediated Transport Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis	Intracellular Protein Transport Endocytosis Actin Filament Organization Sensory Perception Of Sound Intracellular Protein Localization Response To Xenobiotic Stimulus Protein Transport Actin Filament-based Movement DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Regulation Of Secretion
Pathways		Gap junction degradation Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Gap junction degradation Trafficking of AMPA receptors RHOBTB2 GTPase cycle RHOU GTPase cycle RHOBTB1 GTPase cycle
Drugs
Diseases			Deafness, autosomal recessive Deafness, autosomal dominant
GWAS		Obesity-related traits ( 23251661)	Hip circumference adjusted for BMI ( 34021172) Prostate cancer ( 25217961) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		11 interacting genes: CALM1 CEBPA CLTC CSNK2A1 CSNK2A2 HIP1 HIP1R HTR4 MYO6 PQBP1 SNCA	24 interacting genes: ACTA1 APC CALCOCO2 CALM2 CDC42 CDH1 CLTB DAB1 DAB2 DLG1 GIPC1 LRCH3 OPTN PAK1 PAK3 PRMT2 RNF11 RNF26 SEPTIN9 SNCA TAX1BP1 TOM1L2 UBC WBP2
Entrez ID		1212	4646
HPRD ID		00352	02985
Ensembl ID		ENSG00000175416	ENSG00000196586
Uniprot IDs		B4DTF9 P09497	A0A0A0MRM8 A0A1Y0BRN3 A0A590UJ40 Q9UM54
PDB IDs			2N0Z 2N10 2N11 2N12 2N13 6E5N 6J56 8W41
Enriched GO Terms of Interacting Partners?		Clathrin Light Chain Binding Endocytosis Clathrin-coated Vesicle Clathrin Coat Assembly Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Import Into Cell Protein Kinase CK2 Complex Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Clathrin-coated Vesicle Membrane Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Clathrin-coated Pit Postsynapse Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Vesicle-mediated Transport Protein-containing Complex Regulation Of Protein Catabolic Process Regulation Of Protein Stability Negative Regulation Of Protein Catabolic Process Clathrin Adaptor Activity Phospholipid Binding Actin Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Clathrin-coated Endocytic Vesicle PcG Protein Complex Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Receptor-mediated Endocytosis Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Cortex Supramolecular Fiber Organization Positive Regulation Of ERBB Signaling Pathway Clathrin Binding Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Component Organization Actin Filament Binding Regulation Of Cell Cycle Presynaptic Endocytosis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Long-term Synaptic Potentiation Mitochondrion Organization Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macrophage Activation Actin Filament Organization Cortical Actin Cytoskeleton Large Intestinal Transit Minus-end Directed Microfilament Motor Activity Response To Desipramine	Perinuclear Region Of Cytoplasm Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Cytoplasm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Intracellular Protein Localization Regulation Of Supramolecular Fiber Organization Cytosol Regulation Of Organelle Organization Septin Cytoskeleton Organization Protein Kinase Binding Cell Junction Organization Presynaptic Endocytosis Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Cell Cycle Process Regulation Of Axonogenesis Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Cadherin Binding Regulation Of Cytoskeleton Organization Leading Edge Membrane Cell-cell Junction Organization Positive Regulation Of Cellular Component Organization Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Glutamatergic Synapse Regulation Of Defense Response Lateral Plasma Membrane Negative Regulation Of Cell Cycle G1/S Phase Transition Gamma-catenin Binding Lamellipodium Positive Regulation Of Pseudopodium Assembly Regulation Of Protein Catabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cell Migration Golgi Localization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Mitotic Cell Cycle Autophagosome Regulation Of Cytokinesis Regulation Of Protein-containing Complex Assembly Vesicle-mediated Transport In Synapse Dendritic Spine Morphogenesis Regulation Of Neuron Projection Development Endocytosis Regulation Of Microtubule Polymerization Or Depolymerization
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