CLTB and HIP1R

Number of citations of the paper that reports this interaction (PMID 15533940)
30

Data Source:
HPRD (two hybrid, in vitro)

		CLTB	HIP1R
Gene Name		clathrin, light chain B	huntingtin interacting protein 1 related
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Trans-Golgi Network Plasma Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Intracellular Membrane-bounded Organelle Ciliary Membrane	Cytoplasm Cytoskeleton Coated Pit Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Structural Molecule Activity Protein Binding Peptide Binding	Actin Binding Protein Binding Protein Binding, Bridging Phosphatidylinositol Binding
	Biological Process	Intracellular Protein Transport Vesicle-mediated Transport	Receptor-mediated Endocytosis Actin Cytoskeleton Organization
Pathways		Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Axon guidance Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking WNT5A-dependent internalization of FZD4 EPH-Ephrin signaling Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Parkinson's disease ( 21292315)
Protein-Protein Interactions		7 interactors: CALM1 CLTC CSNK2A1 CSNK2A2 HIP1 HIP1R PQBP1	8 interactors: ACTA1 CLTA CLTB CLTC CTTN DYNLL1 HIP1 HTT
Entrez ID		1212	9026
HPRD ID		00352	10412
Ensembl ID		ENSG00000175416	ENSG00000130787
Uniprot IDs		P09497	B3KN98 B3KQW8 O75146 Q6NXG8
PDB IDs			1R0D
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Division Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Cellular Component Organization Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Regulation Of Cell Cycle Process Negative Regulation Of Chromosome Organization Vesicle-mediated Transport Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Endocytosis Organelle Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Mitotic Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Hyaluronan Biosynthetic Process Developmental Process Mitotic Cell Cycle Checkpoint Mitotic Cell Cycle Cell Differentiation Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Cellular Protein Metabolic Process Neuron Projection Development Regulation Of Cellular Protein Metabolic Process Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Proteasomal Protein Catabolic Process Membrane Organization Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Chromosome Organization Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Protein Metabolic Process Neuron Development Apoptotic Process	Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Intracellular Protein Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cytoskeleton Organization Actin Cytoskeleton Organization Cellular Protein Localization Actin Filament-based Process Protein Transport Endocytosis Establishment Of Protein Localization Antigen Processing And Presentation Of Peptide Antigen Intracellular Transport Golgi Vesicle Transport Antigen Processing And Presentation Membrane Organization Transport Organelle Organization Protein Localization Establishment Of Localization In Cell Cell Differentiation Developmental Process Neural Plate Formation Post-Golgi Vesicle-mediated Transport Cellular Localization Anatomical Structure Morphogenesis Serotonin Uptake Skeletal Muscle Fiber Adaptation Lactate Biosynthetic Process From Pyruvate Regulation Of Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Protein Phosphatase Type 2A Activity Regulation Of Cell Death Mitotic Cell Cycle Process Quinolinate Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Transport Mitotic Cell Cycle Lactate Biosynthetic Process Cell Development Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Paraxial Mesoderm Formation Cellular Component Assembly Quinolinate Metabolic Process
Tagcloud ?			avoided balanced ccdc62 desipramine dextromethorphan escitalopram favorably fluoxetine gba gdnf haloperidol investigative lithium mapt neurogenesis neuroinflammation neuroprotective pathobiological pathobiology pramipexole priorities proteasomal psychotropics replicated rns safest salutary trophic valproate
Tagcloud (Difference) ?			avoided balanced ccdc62 desipramine dextromethorphan escitalopram favorably fluoxetine gba gdnf haloperidol investigative lithium mapt neurogenesis neuroinflammation neuroprotective pathobiological pathobiology pramipexole priorities proteasomal psychotropics replicated rns safest salutary trophic valproate
Tagcloud (Intersection) ?