CLTB and HIP1R

Number of citations of the paper that reports this interaction (PubMedID 11889126)
0

Data Source:
HPRD (two hybrid, in vitro)

		CLTB	HIP1R
Description		clathrin light chain B	huntingtin interacting protein 1 related
Image		No pdb structure
GO Annotations	Cellular Component	Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin Coat Clathrin Vesicle Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Clathrin-coated Endocytic Vesicle Ciliary Membrane Presynaptic Endocytic Zone Membrane	Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Cell Cortex Endomembrane System Postsynaptic Density Membrane Apical Plasma Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Cortical Actin Cytoskeleton Cytoplasmic Vesicle Ruffle Membrane Dendrite Cytoplasm Neuronal Cell Body Dendritic Spine Perinuclear Region Of Cytoplasm Synaptic Membrane Postsynapse Postsynaptic Endocytic Zone Glutamatergic Synapse
	Molecular Function	Structural Molecule Activity Protein Binding Clathrin Heavy Chain Binding Peptide Binding	Actin Binding Protein Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding SH3 Domain Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol Binding Clathrin Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Intracellular Protein Transport Vesicle-mediated Transport Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis	Endocytosis Receptor-mediated Endocytosis Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Clathrin Coat Assembly Protein Stabilization Positive Regulation Of Transport Positive Regulation Of Cellular Component Organization Digestive System Development Regulation Of Gastric Acid Secretion Membrane Organization Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Postsynapse Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Clathrin Coat Assembly Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Gap junction degradation Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	A body shape index ( 34021172) Atrial fibrillation ( 29892015 30061737) Body mass index ( 29273807) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean platelet volume ( 32888494) Parkinson's disease ( 21292315) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 30285260) Tourette syndrome ( 30818990) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		11 interacting genes: CALM1 CEBPA CLTC CSNK2A1 CSNK2A2 HIP1 HIP1R HTR4 MYO6 PQBP1 SNCA	13 interacting genes: ACTA1 ACTB CLTA CLTB CLTC CTTN DYNLL1 EPN1 HIP1 HTT TFIP11 TRIM27 UBC
Entrez ID		1212	9026
HPRD ID		00352	10412
Ensembl ID		ENSG00000175416	ENSG00000130787
Uniprot IDs		B4DTF9 P09497	B3KQW8 B4DPL0 O75146
PDB IDs			1R0D
Enriched GO Terms of Interacting Partners?		Clathrin Light Chain Binding Endocytosis Clathrin-coated Vesicle Clathrin Coat Assembly Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Import Into Cell Protein Kinase CK2 Complex Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Clathrin-coated Vesicle Membrane Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Clathrin-coated Pit Postsynapse Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Vesicle-mediated Transport Protein-containing Complex Regulation Of Protein Catabolic Process Regulation Of Protein Stability Negative Regulation Of Protein Catabolic Process Clathrin Adaptor Activity Phospholipid Binding Actin Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Clathrin-coated Endocytic Vesicle PcG Protein Complex Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Receptor-mediated Endocytosis Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Cortex Supramolecular Fiber Organization Positive Regulation Of ERBB Signaling Pathway Clathrin Binding Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Component Organization Actin Filament Binding Regulation Of Cell Cycle Presynaptic Endocytosis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Long-term Synaptic Potentiation Mitochondrion Organization Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macrophage Activation Actin Filament Organization Cortical Actin Cytoskeleton Large Intestinal Transit Minus-end Directed Microfilament Motor Activity Response To Desipramine	Cytosol Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin-coated Pit Clathrin Coat Of Coated Pit Clathrin Vesicle Coat Vesicle-mediated Transport Presynaptic Endocytic Zone Membrane Clathrin Coat Assembly Clathrin-coated Endocytic Vesicle Cytoplasm Endocytosis Clathrin-dependent Endocytosis Intracellular Transport Nitric-oxide Synthase Regulator Activity Receptor-mediated Endocytosis Import Into Cell Cytoplasmic Vesicle Membrane Clathrin Complex Clathrin Light Chain Binding Postsynaptic Actin Cytoskeleton Clathrin Heavy Chain Binding Profilin Binding Cytoskeleton Regulation Of Cellular Component Organization Clathrin-coated Vesicle Cellular Localization Establishment Of Localization In Cell Actin Filament Regulation Of Organelle Organization Neuron Projection Morphogenesis Structural Constituent Of Cytoskeleton Cell Projection Morphogenesis Endolysosome Membrane Intracellular Protein Transport Developmental Process Cortical Cytoskeleton Peptide Binding Plasma Membrane Bounded Cell Projection Assembly Face Morphogenesis Cell Projection Assembly Axonogenesis Protein Transport Dynein Intermediate Chain Binding Clathrin Binding Cell Projection Organization Lamellipodium Anatomical Structure Homeostasis Tissue Homeostasis Substantia Nigra Development
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