ABCA3

Name	ATP binding cassette subfamily A member 3
Structure
Interactors	1 interactors: HTR2B
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Plasma Membrane Endomembrane System Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Multivesicular Body Membrane Lamellar Body Intracellular Membrane-bounded Organelle Alveolar Lamellar Body Lamellar Body Membrane Alveolar Lamellar Body Membrane
	Molecular Function	Nucleotide Binding Lipid Transporter Activity ATP Binding ABC-type Xenobiotic Transporter Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Phosphatidylcholine Transfer Activity ATPase-coupled Intramembrane Lipid Transporter Activity Phosphatidylcholine Flippase Activity ABC-type Transporter Activity
	Biological Process	Xenobiotic Transmembrane Transport Lipid Transport Response To Xenobiotic Stimulus Positive Regulation Of Cholesterol Efflux Phospholipid Transport Lung Development Regulation Of Lipid Transport Positive Regulation Of Protein Homooligomerization Lipid Translocation Xenobiotic Transport Surfactant Homeostasis Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Xenobiotic Export From Cell Regulation Of Lipid Biosynthetic Process Response To Glucocorticoid Transmembrane Transport Phospholipid Homeostasis Organelle Assembly Intermembrane Lipid Transfer Regulation Of Phosphatidylcholine Metabolic Process Positive Regulation Of Phospholipid Efflux Positive Regulation Of Phospholipid Transport
Pathways	ABC transporters in lipid homeostasis Defective ABCA3 causes SMDP3 Surfactant metabolism Defective ABCA3 causes SMDP3
Diseases	Pulmonary surfactant metabolism dysfunction (SMDP)
GWAS	Birth weight ( 31043758 ) RR interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329 ) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429 ) Trunk fat mass ( 28552196 )
Entrez ID	21
HPRD ID	03369
Ensembl ID	ENSG00000167972
Uniprot IDs	Q99758
PDB IDs	7W01 7W02
GO Terms Enriched among Interactors ?	Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process G Protein-coupled Serotonin Receptor Complex Intestine Smooth Muscle Contraction Serotonin Binding Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Activity Neural Crest Cell Differentiation Positive Regulation Of Phospholipid Biosynthetic Process Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Activity Regulation Of Phospholipid Biosynthetic Process Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Cardiac Muscle Hypertrophy G-protein Alpha-subunit Binding CGMP-mediated Signaling Muscle Hypertrophy Vasoconstriction Regulation Of Phospholipid Metabolic Process Smooth Muscle Contraction ERK1 And ERK2 Cascade Release Of Sequestered Calcium Ion Into Cytosol G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Heart Morphogenesis Neural Crest Cell Migration Negative Regulation Of Sequestering Of Calcium Ion Mesenchymal Cell Migration Regulation Of Behavior Calcium Ion Transmembrane Import Into Cytosol Positive Regulation Of Cell Division Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Lipid Biosynthetic Process Stem Cell Differentiation Mesenchymal Cell Differentiation Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Sequestering Of Calcium Ion Ameboidal-type Cell Migration Positive Regulation Of Lipid Metabolic Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Endothelial Cell Proliferation Calcium-mediated Signaling Regulation Of Cell Division Intracellular Calcium Ion Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Lipid Biosynthetic Process Calcium Ion Transmembrane Transport Positive Regulation Of Epithelial Cell Proliferation Muscle Contraction