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HTR1B and MDFI
Number of citations of the paper that reports this interaction (PMID
24722188
)
1
Data Source:
BioGRID
(two hybrid, two hybrid)
HTR1B
MDFI
Gene Name
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
MyoD family inhibitor
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Nucleus
Cytoplasm
Molecular Function
Serotonin Receptor Activity
Drug Binding
Serotonin Binding
Protein Binding
Transcription Factor Binding
Biological Process
G-protein Coupled Receptor Internalization
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway
Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway
Synaptic Transmission
Regulation Of Dopamine Secretion
Negative Regulation Of Serotonin Secretion
Negative Regulation Of CAMP Biosynthetic Process
Negative Regulation Of Synaptic Transmission, GABAergic
Cellular Response To Drug
Response To Cocaine
Vasoconstriction
Drinking Behavior
Response To Ethanol
Bone Remodeling
Regulation Of Behavior
Response To Mineralocorticoid
Negative Regulation Of Synaptic Transmission, Glutamatergic
Cellular Response To Alkaloid
Cellular Response To Temperature Stimulus
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Activation Of JUN Kinase Activity
Embryo Development
Dorsal/ventral Axis Specification
Negative Regulation Of Wnt Signaling Pathway
Cytoplasmic Sequestering Of Transcription Factor
Negative Regulation Of DNA Binding
Embryonic Skeletal System Morphogenesis
Trophoblast Giant Cell Differentiation
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
GPCR downstream signaling
Class A/1 (Rhodopsin-like receptors)
Amine ligand-binding receptors
G alpha (i) signalling events
Metabolic disorders of biological oxidation enzymes
GPCR ligand binding
Serotonin receptors
Drugs
Eletriptan
Ziprasidone
Cabergoline
Ropinirole
Zolmitriptan
Dihydroergotamine
Olanzapine
Clozapine
Pramipexole
Propranolol
Lisuride
Sumatriptan
Ergotamine
Apomorphine
Ondansetron
Almotriptan
Naratriptan
Rizatriptan
Pindolol
Frovatriptan
Pergolide
Bromocriptine
Quetiapine
Aripiprazole
Yohimbine
Asenapine
Bopindolol
Diseases
GWAS
Protein-Protein Interactions
3 interactors:
HTR1A
HTR1D
MDFI
225 interactors:
AANAT
AASDHPPT
ADAMTSL3
AKAP17A
AP5Z1
APLN
AQP1
AQP5
ARHGAP32
ARID5A
ATG12
ATN1
ATXN7L2
AVPI1
B3GNT9
BAALC
BAHD1
BBS2
BEX1
C10orf62
C14orf105
C17orf70
C19orf60
C19orf66
C20orf195
C22orf39
C4orf26
C5orf30
C6orf165
C8orf33
C8orf48
CATSPER1
CBFA2T2
CBX2
CC2D1B
CCDC116
CCDC120
CCDC185
CCDC33
CCER1
CDC42EP1
CDCA7L
CDKL3
CEP57L1
CHIC2
CLPB
CNNM3
CPSF3L
CREB5
CRX
CRY1
CSNK1G2-AS1
CXCL16
CYBA
DAAM2
DBF4B
DCAF8
DCANP1
DDX19A
DHRS1
DKK1
DMRT3
DNPEP
DOCK2
DUSP6
EBI3
EIF4A2
EIF4E2
ENKD1
ETNK2
EWSR1
FAM124B
FAM161A
FAM27E3
FASTK
FBXL18
FBXO34
FBXW5
FES
FOXD4L6
FZD9
GATA2
GDF15
GLIDR
GNAI2
GNG5
GPATCH2L
GPRIN2
GTF3C5
HEYL
HNRNPLL
HOXA1
HOXB9
HTR1B
ILF3
IQUB
KAT5
KIAA0040
KIAA0408
KIF1A
KPNA2
KRAS
LASP1
LCE1B
LCE3E
LCE4A
LIMS2
LINC00636
LINC01588
LMO3
LOC148413
LOC149950
LRCH4
LRRN4
MAGED1
MAGEF1
MAPKBP1
MCM5
METTL17
MFSD3
MGAT5B
MVP
MYF5
MYOD1
MYOG
NAB2
NDUFA7
NEU4
NPDC1
NR1H2
NR1H3
OLIG3
OTX1
PARP11
PBXIP1
PDGFB
PDIA5
PGLS
PHLDA1
PID1
PIDD1
PIH1D2
PIN1
PLEKHG4
POM121L8P
PRKAB2
PTPMT1
PVRL2
RABL6
REG3A
RFX2
RIPPLY1
RTP5
SERF2
SFI1
SIX1
SLC25A10
SLC35A2
SLC9A1
SPATA3
SPATA8
SPG7
SPRY1
SPRY2
TAP1
TCEB3
TCF3
TGIF1
THAP7
THEG
TIE1
TINAGL1
TMEM241
TNNI1
TNP2
TRAF3IP2
TRPC1
TRPV6
TSC2
TTC23
TTLL10
TUSC2
TYMSOS
TYRO3
UBC
USP20
USP6
VHL
VPS72
WDYHV1
WNT11
ZBTB24
ZBTB25
ZBTB9
ZFYVE26
ZNF101
ZNF124
ZNF136
ZNF138
ZNF155
ZNF205
ZNF223
ZNF230
ZNF264
ZNF266
ZNF408
ZNF417
ZNF426
ZNF433
ZNF439
ZNF440
ZNF490
ZNF559
ZNF564
ZNF578
ZNF581
ZNF587
ZNF607
ZNF646
ZNF670
ZNF679
ZNF707
ZNF764
ZNF79
ZNF844
Entrez ID
3351
4188
HPRD ID
01634
07280
Ensembl ID
ENSG00000112559
Uniprot IDs
P28222
B1AKB6
Q99750
PDB IDs
2G1X
4IAQ
4IAR
Enriched GO Terms of Interacting Partners
?
Serotonin Receptor Signaling Pathway
Vasoconstriction
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Regulation Of Blood Vessel Size
Regulation Of Tube Size
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Regulation Of Behavior
Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway
Intestine Smooth Muscle Contraction
Blood Circulation
Regulation Of Serotonin Secretion
Serotonin Metabolic Process
Trophoblast Giant Cell Differentiation
Regulation Of Dopamine Metabolic Process
Cytoplasmic Sequestering Of Transcription Factor
Dorsal/ventral Axis Specification
Cytoplasmic Sequestering Of Protein
Exploration Behavior
Cell Differentiation Involved In Embryonic Placenta Development
Behavioral Fear Response
Activation Of JUN Kinase Activity
Fear Response
Negative Regulation Of DNA Binding
Regulation Of Cellular Localization
Negative Regulation Of Transcription Factor Import Into Nucleus
G-protein Coupled Receptor Signaling Pathway
Smooth Muscle Contraction
Positive Regulation Of JUN Kinase Activity
Negative Regulation Of Protein Import Into Nucleus
Regulation Of JUN Kinase Activity
Negative Regulation Of Protein Localization To Nucleus
Regulation Of DNA Binding
JNK Cascade
Signal Transduction
Negative Regulation Of Intracellular Protein Transport
Multicellular Organismal Response To Stress
Regulation Of Transcription Factor Import Into Nucleus
Negative Regulation Of Binding
Phenol-containing Compound Metabolic Process
Signaling
Axis Specification
Cell Communication
Embryonic Placenta Development
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Negative Regulation Of Intracellular Transport
Dorsal/ventral Pattern Formation
Positive Regulation Of JNK Cascade
Embryonic Skeletal System Morphogenesis
Transcription, DNA-templated
RNA Biosynthetic Process
Macromolecule Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
RNA Metabolic Process
Gene Expression
Regulation Of RNA Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Gene Expression
Biosynthetic Process
Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Regulation Of Cellular Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Cellular Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Cellular Metabolic Process
Negative Regulation Of Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Developmental Process
Cellular Response To Organic Substance
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Multicellular Organismal Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cell Differentiation
Positive Regulation Of Myoblast Fusion
Cell Fate Commitment
Positive Regulation Of Skeletal Muscle Fiber Development
Anatomical Structure Development
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion
Regulation Of Myoblast Fusion
Transcription From RNA Polymerase II Promoter
Organ Development
Metabolic Process
Tagcloud
?
1n9c
acsl3
agpat3
bovinesnp50
bta1
c10
c12
c14
c18
chuk
dgat1
echs1
ehhadh
groundwork
lipj
lipk
minpp1
mogat1
nfkb2
osbpl8
oxct1
plink
prkg1
scd1
sfa
sorbs1
ufa
underling
unraveling
Tagcloud (Difference)
?
1n9c
acsl3
agpat3
bovinesnp50
bta1
c10
c12
c14
c18
chuk
dgat1
echs1
ehhadh
groundwork
lipj
lipk
minpp1
mogat1
nfkb2
osbpl8
oxct1
plink
prkg1
scd1
sfa
sorbs1
ufa
underling
unraveling
Tagcloud (Intersection)
?