HTR1B

Description		5-hydroxytryptamine receptor 1B
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Plasma Membrane Membrane Dendrite Presynaptic Membrane G Protein-coupled Serotonin Receptor Complex Serotonergic Synapse
	Molecular Function	Gi/o-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Negative Regulation Of Serotonin Secretion Vasoconstriction Bone Remodeling Regulation Of Behavior Cellular Response To Alkaloid Cellular Response To Xenobiotic Stimulus Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Serotonin receptors G alpha (i) signalling events
Drugs		Eletriptan Ziprasidone Methysergide Cabergoline Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Loxapine Amoxapine Propranolol Lisuride Sumatriptan Ergotamine Apomorphine Paroxetine Ondansetron Almotriptan Oxymetazoline Naratriptan Rizatriptan Pindolol Frovatriptan Ergoloid mesylate Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Penbutolol Yohimbine Dapoxetine NXN-188 Pizotifen Asenapine Nandrolone decanoate Bopindolol Vortioxetine Setiptiline Dihydroergocornine Gilteritinib Lecozotan Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Brain volume in infants (white matter) ( 28763065) Early chronic obstructive pulmonary disease in never smokers ( 33235445) HDL cholesterol levels in HIV infection ( 33109212) Psychological distress ( 30705256) Response to fenofibrate (total cholesterol levels) ( 27002377)
Interacting Genes		5 interacting genes: ACTN2 HTR1A HTR1D MDFI SNCA
Entrez ID		3351
HPRD ID		01634
Ensembl ID		ENSG00000135312
Uniprot IDs		A8K215 P28222 X5D7I5
PDB IDs		4IAQ 4IAR 5V54 6G79 7C61
Enriched GO Terms of Interacting Partners?		Gi/o-coupled Serotonin Receptor Activity G Protein-coupled Serotonin Receptor Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Receptor Activity Regulation Of Dopamine Metabolic Process Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Synapse Chemical Synaptic Transmission Protein Sequestering Activity Trans-synaptic Signaling Synaptic Signaling G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Monoatomic Ion Transport Regulation Of Behavior Actin Filament Uncapping Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phenol-containing Compound Metabolic Process Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cell-cell Signaling Positive Regulation Of Cation Transmembrane Transport Signaling Titin Z Domain Binding Positive Regulation Of Monoatomic Ion Transmembrane Transport Cell Communication Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Phospholipase C-activating Angiotensin-activated Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Blood Vessel Diameter Maintenance Regulation Of Tube Size Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy G Protein-coupled Receptor Signaling Pathway Microspike Assembly Positive Regulation Of Monoatomic Ion Transport Receptor-receptor Interaction Intestine Smooth Muscle Contraction Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake FATZ Binding Regulation Of Serotonin Secretion Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process
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