HTR1B

Gene Name		5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
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Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Serotonin Receptor Activity Drug Binding Serotonin Binding
	Biological Process	G-protein Coupled Receptor Internalization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Regulation Of Dopamine Secretion Negative Regulation Of Serotonin Secretion Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of Synaptic Transmission, GABAergic Cellular Response To Drug Response To Cocaine Vasoconstriction Drinking Behavior Response To Ethanol Bone Remodeling Regulation Of Behavior Response To Mineralocorticoid Negative Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To Alkaloid Cellular Response To Temperature Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs		Eletriptan Ziprasidone Cabergoline Ropinirole Zolmitriptan Dihydroergotamine Olanzapine Clozapine Pramipexole Propranolol Lisuride Sumatriptan Ergotamine Apomorphine Ondansetron Almotriptan Naratriptan Rizatriptan Pindolol Frovatriptan Pergolide Bromocriptine Quetiapine Aripiprazole Yohimbine Asenapine Bopindolol
Diseases
GWAS
Protein-protein Interactions		3 interactors: HTR1A HTR1D MDFI
Entrez ID		3351
HPRD ID		01634
Ensembl ID
Uniprot IDs		P28222
PDB IDs		2G1X 4IAQ 4IAR
Enriched GO Terms of Interacting Partners?		Serotonin Receptor Signaling Pathway Vasoconstriction Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Tube Size Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Behavior Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Intestine Smooth Muscle Contraction Blood Circulation Regulation Of Serotonin Secretion Serotonin Metabolic Process Trophoblast Giant Cell Differentiation Regulation Of Dopamine Metabolic Process Cytoplasmic Sequestering Of Transcription Factor Dorsal/ventral Axis Specification Cytoplasmic Sequestering Of Protein Exploration Behavior Cell Differentiation Involved In Embryonic Placenta Development Behavioral Fear Response Activation Of JUN Kinase Activity Fear Response Negative Regulation Of DNA Binding Regulation Of Cellular Localization Negative Regulation Of Transcription Factor Import Into Nucleus G-protein Coupled Receptor Signaling Pathway Smooth Muscle Contraction Positive Regulation Of JUN Kinase Activity Negative Regulation Of Protein Import Into Nucleus Regulation Of JUN Kinase Activity Negative Regulation Of Protein Localization To Nucleus Regulation Of DNA Binding JNK Cascade Signal Transduction Negative Regulation Of Intracellular Protein Transport Multicellular Organismal Response To Stress Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Binding Phenol-containing Compound Metabolic Process Signaling Axis Specification Cell Communication Embryonic Placenta Development Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Intracellular Transport Dorsal/ventral Pattern Formation Positive Regulation Of JNK Cascade Embryonic Skeletal System Morphogenesis
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