MGAT3

Description		beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity
	Biological Process	N-acetylglucosamine Metabolic Process Protein Glycosylation Protein N-linked Glycosylation Intracellular Protein Localization Regulation Of Cell Migration Cellular Response To Oxidative Stress Amyloid-beta Metabolic Process Cognition Positive Regulation Of Protein Localization To Early Endosome Negative Regulation Of Lysosomal Protein Catabolic Process
Pathways		Reactions specific to the hybrid N-glycan synthesis pathway
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) General cognitive ability ( 29844566) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Post bronchodilator FEV1 ( 26634245) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 29483656) Sleep duration (short sleep) ( 30846698)
Novel Interacting Genes		1 novel interacting genes: HSPD1
Interacting Genes		1 interacting genes: UBAC1
Entrez ID		4248
HPRD ID		07058
Ensembl ID		ENSG00000128268
Uniprot IDs		Q09327
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitochondrial Unfolded Protein Response Isotype Switching To IgG Isotypes Protein Maturation Lipopolysaccharide Receptor Complex Migrasome Coated Vesicle Protein Import Into Mitochondrial Intermembrane Space Apolipoprotein A-I Binding Cellular Response To Unfolded Protein MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Interleukin-7 Adhesion Of Symbiont To Host Regulation Of T Cell Mediated Immune Response To Tumor Cell Response To Interleukin-7 Positive Regulation Of Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell High-density Lipoprotein Particle Binding Sperm Plasma Membrane Apolipoprotein Binding Negative Regulation Of Execution Phase Of Apoptosis 'de Novo' Protein Folding Cysteine-type Endopeptidase Activator Activity DNA Replication Origin Binding Proteasome Binding Positive Regulation Of Execution Phase Of Apoptosis Chaperone-mediated Protein Complex Assembly Isotype Switching Positive Regulation Of Macrophage Activation Regulation Of Response To Tumor Cell Positive Regulation Of Interferon-alpha Production Somatic Diversification Of Immunoglobulins Involved In Immune Response Cellular Response To Topologically Incorrect Protein Protein Refolding Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Recombination Of Immunoglobulin Gene Segments ATP-dependent Protein Folding Chaperone Lipopolysaccharide Binding Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Protein Localization To Mitochondrion Response To Cold Biological Process Involved In Interaction With Symbiont Somatic Diversification Of Immunoglobulins B Cell Proliferation Polyubiquitin Modification-dependent Protein Binding Somatic Cell DNA Recombination Toll-like Receptor Signaling Pathway Sperm Midpiece Regulation Of Macrophage Activation B Cell Activation Involved In Immune Response
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