CD58

Name	CD58 molecule
Structure
Interactors	4 interactors: APP CD2 DNAJA1 HERPUD1
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding
	Biological Process	Immune Response Positive Regulation Of Interleukin-8 Production Heterotypic Cell-cell Adhesion Cellular Response To Type II Interferon Cellular Response To Tumor Necrosis Factor Cell-cell Adhesion
Pathways	Cell surface interactions at the vascular wall Neutrophil degranulation
GWAS	Multiple sclerosis ( 19525953 19525955 21244703 21833088 22190364 24076602 27386562 31604244 ) Primary biliary cholangitis ( 28425483 ) Systemic lupus erythematosus ( 33272962 33536424 )
Entrez ID	965
HPRD ID	01081
Ensembl ID	ENSG00000116815
Uniprot IDs	P19256
PDB IDs	1CCZ 1CI5 1QA9
GO Terms Enriched among Interactors ?	Regulation Of Intrinsic Apoptotic Signaling Pathway Low-density Lipoprotein Particle Receptor Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Signaling Pathway Protein-folding Chaperone Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of Toll Signaling Pathway G Protein-coupled Receptor Binding Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Type II Interferon Production Regulation Of Cellular Response To Stress Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Unfolded Protein Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Type II Interferon Production Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of JNK Cascade Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Membrane Raft Polarization Positive Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway Lewy Body Core Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Catabolic Process Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Response To Stress Positive Regulation Of Amyloid Fibril Formation