SESTD1 and IQCB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SESTD1	IQCB1
Description		SEC14 and spectrin domain containing 1	IQ motif containing B1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Calcium Channel Complex Intermediate Filament Cytoskeleton	Photoreceptor Outer Segment Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Photoreceptor Connecting Cilium Extracellular Exosome
	Molecular Function	Phosphatidylserine Binding Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylcholine Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding Calmodulin Binding Enzyme Binding Protein-macromolecule Adaptor Activity BBSome Binding
	Biological Process	Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Cell Projection Organization Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Cilium Assembly Cytosolic Ciliogenesis
Pathways			Anchoring of the basal body to the plasma membrane
Drugs
Diseases			Senior-Loken syndrome
GWAS		Late-onset Alzheimer's disease ( 27770636) Objective response to lithium treatment ( 26503763) Optic disc size ( 31809533) Presence of antiphospholipid antibodies ( 23509613) Refractive error ( 32231278) Serum uric acid levels ( 29559957)	Hemoglobin levels ( 32327693) Multiple sclerosis ( 24076602 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376)
Interacting Genes		10 interacting genes: CBX8 GPS2 HSF4 IQCB1 NRIP1 RABGEF1 STMN1 STMN2 TEAD4 ZNF830	12 interacting genes: CALM2 CALML3 KIF9 LDOC1 MARCHF7 MNS1 PCMT1 PDE9A SESTD1 SMARCD1 SPG21 TRIM32
Entrez ID		91404	9657
HPRD ID		11549	11049
Ensembl ID		ENSG00000187231	ENSG00000173226
Uniprot IDs		B3KTX3 Q86VW0	Q15051
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Microtubule Polymerization Microtubule Depolymerization Microtubule Polymerization Or Depolymerization Protein Depolymerization Ovulation Cycle Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Tubulin Binding Negative Regulation Of Small GTPase Mediated Signal Transduction Trophectodermal Cell Fate Commitment Ovarian Follicle Rupture Regulation Of Microtubule Polymerization BBSome Binding Negative Regulation Of Kit Signaling Pathway Negative Regulation Of Mast Cell Cytokine Production Preantral Ovarian Follicle Growth Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Negative Regulation Of Transcription By RNA Polymerase II Nuclear Speck Regulation Of Microtubule Polymerization Or Depolymerization Kit Signaling Pathway Intracellular Signal Transduction Transcription Coregulator Activity Chromatin Maintenance Of Animal Organ Identity Negative Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Microtubule Depolymerization	Detection Of Calcium Ion Regulation Of Cilium Assembly Regulation Of Organelle Assembly Calcium Channel Complex Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Calcium Ion Transmembrane Transport Calcineurin-mediated Signaling Myelin Sheath Negative Regulation Of Cell Population Proliferation Regulation Of Organelle Organization Thyrotropin-releasing Hormone Activity Positive Regulation Of Interleukin-17-mediated Signaling Pathway Negative Regulation Of Cilium Assembly Actin Ubiquitination Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production
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