HSD17B4 and CASP9

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HSD17B4	CASP9
Gene Name		hydroxysteroid (17-beta) dehydrogenase 4	caspase 9, apoptosis-related cysteine peptidase
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Gene Ontology Annotations	Cellular Component	Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Membrane Intracellular Membrane-bounded Organelle	Nucleus Mitochondrion Cytosol Apoptosome
	Molecular Function	3-hydroxyacyl-CoA Dehydrogenase Activity Receptor Binding Long-chain-enoyl-CoA Hydratase Activity Isomerase Activity 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA Hydratase Activity Protein Homodimerization Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity SH3 Domain Binding Protein Kinase Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Osteoblast Differentiation Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Metabolic Process Bile Acid Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Unsaturated Fatty Acid Metabolic Process Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty-acyl-CoA Metabolic Process Medium-chain Fatty-acyl-CoA Metabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Sertoli Cell Development	Proteolysis Apoptotic Process Cellular Response To DNA Damage Stimulus Epidermal Growth Factor Receptor Signaling Pathway Aging Fibroblast Growth Factor Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Platelet Formation Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Glial Cell Apoptotic Process Cellular Response To UV Fc-epsilon Receptor Signaling Pathway Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Response To Antibiotic Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Dexamethasone Stimulus Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Response To DNA Damage Stimulus
Pathways		Beta-oxidation of pristanoyl-CoA Bile acid and bile salt metabolism alpha-linolenic acid (ALA) metabolism Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Metabolism of lipids and lipoproteins alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Synthesis of bile acids and bile salts Beta-oxidation of very long chain fatty acids Peroxisomal lipid metabolism	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling SMAC binds to IAPs SMAC-mediated dissociation of IAP:caspase complexes Cytochrome c-mediated apoptotic response SMAC-mediated apoptotic response Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol Role of DCC in regulating apoptosis Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) Activation of caspases through apoptosome-mediated cleavage Formation of apoptosome PI3K/AKT activation PI-3K cascade Apoptotic factor-mediated response NOD1/2 Signaling Pathway PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Programmed Cell Death Innate Immune System Intrinsic Pathway for Apoptosis Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Extrinsic Pathway Adaptive Immune System
Drugs		NADH Nicotinamide-Adenine-Dinucleotide 3r-Hydroxydecanoyl-Coa
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ACTB BAK1 CASP9 CDK7 MAPK8 NDRG1 SNCA	44 interactors: ABL1 AKT1 APAF1 BCL10 BCL2L1 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BIRC8 CAPN2 CARD8 CASP10 CASP3 CASP7 CASP8 CYCS DCC DIABLO DSP GMEB1 GZMB HIP1 HSD17B4 HSPD1 ILK JUN LYN MAP2K1 MAP2K2 MAPK1 MAPK3 MSTO1 MZB1 NAIP NLRP1 NOD1 PRKCZ RB1 RNF2 SRF VIM XIAP
Entrez ID		3295	842
HPRD ID		03514	03756
Ensembl ID		ENSG00000133835	ENSG00000132906
Uniprot IDs		B2R659 E7ET17 E7EWE5 G5E9S2 P51659	F8VVS7 P55211
PDB IDs		1IKT 1S9C 1ZBQ	1JXQ 1NW9 2AR9 3D9T 3V3K 3YGS
Enriched GO Terms of Interacting Partners?		Response To Inorganic Substance Cellular Response To Stress Response To Metal Ion Response To Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Immune System Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Endopeptidase Activity Response To UV Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Activation Regulation Of Cysteine-type Endopeptidase Activity Response To Other Organism Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Biotic Stimulus Positive Regulation Of Intracellular Transport Protein Processing Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Innate Immune Response Signaling Fc Receptor Signaling Pathway Response To External Stimulus Cellular Response To DNA Damage Stimulus Positive Regulation Of Calcium Ion Transport Into Cytosol Cell Communication Membrane Organization Positive Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Response To Lipopolysaccharide Aging Apoptotic Process Response To Molecule Of Bacterial Origin Response To Light Stimulus Programmed Cell Death Apoptotic Signaling Pathway Positive Regulation Of Hydrolase Activity Cell Death Regulation Of Protein Metabolic Process Death Positive Regulation Of Mitochondrion Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Peptidase Activity Apoptotic Signaling Pathway Zymogen Activation Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Toll-like Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Protein Processing Regulation Of Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Innate Immune Response Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Negative Regulation Of Cell Death
Tagcloud ?		aas aass abused anabolic androgenic arr19 cyp11a1 cyp17a1 dax1 disturbed enanthate gnrhr hsd3b1 hsd3b5 insl3 intramuscular leydig lhcgr milieu oppositely prka prlr1 prlr2 prolactin star steroidogenesis steroidogenic testosterone tspo	10mum abeta42 abeta43 aif carnosic cascades casp3 casp4 casp8 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y
Tagcloud (Difference) ?		aas aass abused anabolic androgenic arr19 cyp11a1 cyp17a1 dax1 disturbed enanthate gnrhr hsd3b1 hsd3b5 insl3 intramuscular leydig lhcgr milieu oppositely prka prlr1 prlr2 prolactin star steroidogenesis steroidogenic testosterone tspo	10mum abeta42 abeta43 aif carnosic cascades casp3 casp4 casp8 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y
Tagcloud (Intersection) ?