HSD17B4 and SNCA

Number of citations of the paper that reports this interaction (PMID 17893145)
17

Data Source:
BioGRID (unspecified method)

		HSD17B4	SNCA
Gene Name		hydroxysteroid (17-beta) dehydrogenase 4	synuclein, alpha (non A4 component of amyloid precursor)
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Membrane Intracellular Membrane-bounded Organelle	Extracellular Region Nucleus Nuclear Outer Membrane Cytoplasm Mitochondrion Mitochondrial Respiratory Chain Complex I Lysosome Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Ribosome Plasma Membrane Cell Cortex Synaptic Vesicle Actin Cytoskeleton Inclusion Body Cell Junction Axon Growth Cone Platelet Alpha Granule Membrane Terminal Bouton Fibril Perinuclear Region Of Cytoplasm
	Molecular Function	3-hydroxyacyl-CoA Dehydrogenase Activity Receptor Binding Long-chain-enoyl-CoA Hydratase Activity Isomerase Activity 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA Hydratase Activity Protein Homodimerization Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity	Magnesium Ion Binding Fatty Acid Binding Copper Ion Binding Calcium Ion Binding Protein Binding Phospholipid Binding Microtubule Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity Kinesin Binding Protein Domain Specific Binding Hsp70 Protein Binding Histone Binding Identical Protein Binding Alpha-tubulin Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Phospholipase Binding Transcription Regulatory Region DNA Binding Dynein Binding Protein N-terminus Binding Tau Protein Binding Beta-tubulin Binding Phosphoprotein Binding Phospholipase D Inhibitor Activity
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Osteoblast Differentiation Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Metabolic Process Bile Acid Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Unsaturated Fatty Acid Metabolic Process Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty-acyl-CoA Metabolic Process Medium-chain Fatty-acyl-CoA Metabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Sertoli Cell Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Microglial Cell Activation Positive Regulation Of Receptor Recycling Negative Regulation Of Protein Phosphorylation Positive Regulation Of Neurotransmitter Secretion Fatty Acid Metabolic Process Neutral Lipid Metabolic Process Phospholipid Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Mitochondrial Membrane Organization Aging Adult Locomotory Behavior Response To Iron(II) Ion Regulation Of Phospholipase Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Negative Regulation Of Microtubule Polymerization Receptor Internalization Protein Destabilization Response To Magnesium Ion Negative Regulation Of Transporter Activity Response To Lipopolysaccharide Negative Regulation Of Monooxygenase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Response To Interferon-gamma Cellular Response To Oxidative Stress Negative Regulation Of Histone Acetylation Regulation Of Locomotion Dopamine Biosynthetic Process Response To Drug Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extracellular Fibril Organization Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Endocytosis Negative Regulation Of Exocytosis Negative Regulation Of Dopamine Metabolic Process Behavioral Response To Cocaine Regulation Of Long-term Neuronal Synaptic Plasticity Synaptic Vesicle Endocytosis Synapse Organization Regulation Of Acyl-CoA Biosynthetic Process Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Negative Regulation Of Norepinephrine Uptake Calcium Ion Homeostasis Oxidation-reduction Process Regulation Of Excitatory Postsynaptic Membrane Potential Long-term Synaptic Potentiation Positive Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Response To Interleukin-1 Cellular Response To Copper Ion Cellular Response To Epinephrine Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Glutathione Peroxidase Activity Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Synaptic Vesicle Recycling Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways		Beta-oxidation of pristanoyl-CoA Bile acid and bile salt metabolism alpha-linolenic acid (ALA) metabolism Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Metabolism of lipids and lipoproteins alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Synthesis of bile acids and bile salts Beta-oxidation of very long chain fatty acids Peroxisomal lipid metabolism	Amyloids
Drugs		NADH Nicotinamide-Adenine-Dinucleotide 3r-Hydroxydecanoyl-Coa
Diseases
GWAS			Parkinson's disease ( 22451204 20711177 21084426 21292315 19915575 19915576 22438815 20070850 21044948 21738487)
Protein-Protein Interactions		7 interactors: ACTB BAK1 CASP9 CDK7 MAPK8 NDRG1 SNCA	110 interactors: A1BG ACTA1 ADAP2 ADRBK1 AKT1 ANXA6 APLP1 APP ARHGAP15 ARPP19 BAD BAG5 BAX BCL2L1 BDH2 CALM1 CAV1 CDC42EP2 CDC42EP3 CDC42SE1 CDK4 COL25A1 COX1 COX3 CRYAB CSNK1A1 CSNK1D CSNK2A1 CSNK2A2 CTNND1 CYCS DMTN DOCK7 DYNC1H1 DYRK1A EEF1A1 EIF3G ELK1 ENC1 ENSA FGR FKBP4 FYN GABARAPL1 GAPDH GRK1 GRK5 GRK6 GSK3B HSD17B4 HSP90AA1 HSPA1A HSPA8 HSPB1 HSPB2 HSPB6 HSPB8 IARS KIAA1191 KLC1 KLK6 LYN MAP1B MAPK1 MAPK8IP1 MAPT MEF2D NEDD4 NEDD4L PAK3 PARK2 PDE4DIP PELP1 PFDN2 PINK1 PLCB2 PLD1 PLK1 PLK2 PLK3 PRDX1 PRKCE PTK2B RABAC1 RNF10 SAP30BP SDF4 SEPT4 SIAH1 SIAH2 SLC6A3 SNCAIP SNCB SPTBN1 SQSTM1 SRC SRI SUMO2 SYK SYN1 TGM1 TH TOR1A TUBA1A UBB UBC USP47 YWHAB YWHAE YWHAH
Entrez ID		3295	6622
HPRD ID		03514	01227
Ensembl ID		ENSG00000133835	ENSG00000145335
Uniprot IDs		B2R659 E7ET17 E7EWE5 G5E9S2 P51659	H6UYS0 H6UYS5 P37840
PDB IDs		1IKT 1S9C 1ZBQ	1XQ8 2JN5 2KKW 2M55 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29
Enriched GO Terms of Interacting Partners?		Response To Inorganic Substance Cellular Response To Stress Response To Metal Ion Response To Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Immune System Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Endopeptidase Activity Response To UV Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Activation Regulation Of Cysteine-type Endopeptidase Activity Response To Other Organism Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Biotic Stimulus Positive Regulation Of Intracellular Transport Protein Processing Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Innate Immune Response Signaling Fc Receptor Signaling Pathway Response To External Stimulus Cellular Response To DNA Damage Stimulus Positive Regulation Of Calcium Ion Transport Into Cytosol Cell Communication Membrane Organization Positive Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Response To Lipopolysaccharide Aging Apoptotic Process Response To Molecule Of Bacterial Origin Response To Light Stimulus Programmed Cell Death Apoptotic Signaling Pathway Positive Regulation Of Hydrolase Activity Cell Death Regulation Of Protein Metabolic Process Death Positive Regulation Of Mitochondrion Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway	Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Localization Cell Death Death Regulation Of Cell Death Apoptotic Process Response To Abiotic Stimulus Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Intracellular Transport Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Cellular Response To Stimulus Regulation Of Proteolysis Positive Regulation Of Metabolic Process Response To Organic Substance Negative Regulation Of Apoptotic Process Nervous System Development Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Stimulus System Development Negative Regulation Of Protein Metabolic Process Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Response To Stress Negative Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Death Cell Communication Cell Differentiation Positive Regulation Of Cellular Protein Metabolic Process Signaling Intracellular Signal Transduction Positive Regulation Of Proteolysis Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Cellular Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Response To External Stimulus Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway
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