HSD17B4

Description		hydroxysteroid 17-beta dehydrogenase 4
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GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane
	Molecular Function	(3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Enoyl-CoA Hydratase Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Oxidoreductase Activity Lyase Activity Isomerase Activity 3-hydroxyacyl-CoA Dehydratase Activity 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA Hydratase Activity Protein Homodimerization Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity (3R)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Osteoblast Differentiation Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Androgen Metabolic Process Estrogen Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty-acyl-CoA Metabolic Process Medium-chain Fatty-acyl-CoA Metabolic Process Long-chain Fatty Acid Biosynthetic Process Sertoli Cell Development Fatty Acid Derivative Biosynthetic Process
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol alpha-linolenic acid (ALA) metabolism Beta-oxidation of pristanoyl-CoA Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs		NADH (R)-3-hydroxydecanoyl-CoA
Diseases		Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia
GWAS		Asthma ( 31959851) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) JT interval (sulfonylurea treatment interaction) ( 27958378) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) QT interval (sulfonylurea treatment interaction) ( 27958378) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Novel Interacting Genes		1 novel interacting genes: FER
Interacting Genes		9 interacting genes: ACTB BAK1 CASP9 CDK7 CEBPA MAPK8 NDRG1 SNCA TIAM1
Entrez ID		3295
HPRD ID		03514
Ensembl ID		ENSG00000133835
Uniprot IDs		A0A0S2Z4J1 A0A2R8Y7L2 A0A804HK65 B2R659 B3KSP2 E7ET17 P51659
PDB IDs		1IKT 1S9C 1ZBQ 6Z1W 6Z1X 8AF2 8AF3
Enriched GO Terms of Interacting Partners?		Regulation Of Norepinephrine Uptake Cellular Response To Stress Transporter Regulator Activity Positive Regulation Of Protein-containing Complex Assembly Intracellular Signal Transduction Fibroblast Apoptotic Process Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Response To Metal Ion Adherens Junction Assembly Protein-containing Complex DNA Damage Response Response To Stress Response To Oxidative Stress Response To Lipid Interleukin-6-mediated Signaling Pathway Regulation Of Protein-containing Complex Assembly Response To UV Fc-epsilon Receptor Signaling Pathway Response To Reactive Oxygen Species Regulation Of Cell Population Proliferation Multicellular Organismal-level Homeostasis Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Cellular Component Biogenesis Adherens Junction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cytosol Cellular Response To Oxidative Stress Positive Regulation Of Cellular Component Organization Kinesin Binding Tau Protein Binding Response To Dexamethasone Regulation Of Cell Activation Leukocyte Apoptotic Process Adherens Junction Organization Actin Cytoskeleton Homeostatic Process Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Response To Xenobiotic Stimulus Response To External Biotic Stimulus Mitochondrion Organization Animal Organ Regeneration Positive Regulation Of Calcium Ion Transmembrane Transport Caspase Complex RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macrophage Activation Fc Receptor Signaling Pathway
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