HOXD3 and HOXA1

Number of citations of the paper that reports this interaction (PMID 23088713)
3

Data Source:
BioGRID (affinity chromatography technology, protein complementation assay)

		HOXD3	HOXA1
Gene Name		homeobox D3	homeobox A1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Protein Binding Sequence-specific DNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell-matrix Adhesion Notch Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Thyroid Gland Development Positive Regulation Of Neuron Differentiation Embryonic Skeletal System Morphogenesis Cartilage Development	Transcription, DNA-templated Multicellular Organismal Development Sensory Perception Of Sound Optokinetic Behavior Motor Neuron Axon Guidance Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Rhombomere 3 Development Rhombomere 4 Development Rhombomere 5 Development Abducens Nerve Formation Facial Nerve Structural Organization Facial Nucleus Development Central Nervous System Neuron Differentiation Outer Ear Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Neurocranium Morphogenesis Inner Ear Development Artery Morphogenesis Regulation Of Behavior Cognition Neuromuscular Process Artery Development Semicircular Canal Formation Cellular Response To Retinoic Acid Cochlea Development Cochlea Morphogenesis
Pathways
Drugs
Diseases
GWAS		Ovarian cancer ( 20852632)
Protein-Protein Interactions		4 interactors: ALX4 DDB1 HMGB1 HOXA1	79 interactors: ABHD17A ADAMTSL4 ALG13 BLZF1 C1orf94 CCDC33 CHIC2 CHRD CRACR2A DUSP22 EFEMP2 FAM154A FHL5 GATA1 GP9 GRN HOXD3 HSFY1 IKZF2 KDM1A KRT31 KRT38 KRT40 KRT81 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-4 KRTAP26-1 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE3E LCE4A LGALS13 LIMS1 LNX2 LPXN MDFI MGAT5B N4BP2L2 NOTCH2NL PBX1 PBX2 PCSK5 PDCD6IP PIK3R1 PITX2 PKNOX1 PLSCR1 PLSCR4 PRMT6 PRRC2B RAB33A RBPMS RGS17 RGS20 SDCBP SPRY1 SUV39H1 TBC1D10C TCF3 TRAF1 TRAPPC6A TRIM42 TRIP6 ZZZ3
Entrez ID		3232	3198
HPRD ID		00863	00843
Ensembl ID		ENSG00000128652	ENSG00000105991
Uniprot IDs		P31249	P49639
PDB IDs
Enriched GO Terms of Interacting Partners?		Optokinetic Behavior Abducens Nerve Formation Negative Regulation Of Apoptotic Cell Clearance Embryonic Skeletal System Morphogenesis DNA Catabolic Process Embryonic Skeletal System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Facial Nucleus Development Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation By Virus Of Viral Protein Levels In Host Cell Rhombomere 4 Development Semicircular Canal Formation Negative Regulation Of DNA-templated Transcription, Initiation Rhombomere 3 Development Rhombomere 5 Development Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Anterior/posterior Pattern Specification Positive Regulation Of Transcription, DNA-templated Base-excision Repair, DNA Ligation Skeletal System Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death UV-damage Excision Repair Embryonic Organ Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Response To Light Stimulus Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation Of Viral Release From Host Cell Embryonic Neurocranium Morphogenesis Nucleobase-containing Compound Metabolic Process DNA Ligation Involved In DNA Repair Outer Ear Morphogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Semicircular Canal Morphogenesis Rhombomere Development Regulation Of Apoptotic Cell Clearance Facial Nerve Structural Organization Pons Development Histone H2A Monoubiquitination Negative Regulation Of Phagocytosis Cellular Nitrogen Compound Metabolic Process Facial Nerve Morphogenesis Response To Radiation Aromatic Compound Catabolic Process DNA Ligation Dendritic Cell Chemotaxis	Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Embryo Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Pattern Specification Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Epidermis Development Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of DNA Binding Regulation Of Protein Import Into Nucleus Regulation Of Transcription Factor Import Into Nucleus Regulation Of Signaling Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Protein Localization To Nucleus Developmental Process Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Signal Transduction Biosynthetic Process RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Negative Regulation Of DNA Binding Keratinization Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Epidermal Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Phospholipid Scrambling Regulation Of Intracellular Protein Transport Gene Expression Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Blood Coagulation
Tagcloud ?		alphavbeta3 characterizes cooperating cyclin d1a d1b damaged ectopic enhance exploration holds indicates introduced invasive invasiveness makes mcf mediator metastatic modulate notably oncogenic poorly promotes released reveal splice toll variant	divergence embryo embryos exert gsc illustrate introduced liganded ligands malformations microinjection nevertheless pleiotropic possess posterior rar reporter responsive responsiveness retinoid retinoids rxr selective striking vertebrate vertebrates xenopus xlim zebrafish
Tagcloud (Difference) ?		alphavbeta3 characterizes cooperating cyclin d1a d1b damaged ectopic enhance exploration holds indicates invasive invasiveness makes mcf mediator metastatic modulate notably oncogenic poorly promotes released reveal splice toll variant	divergence embryo embryos exert gsc illustrate liganded ligands malformations microinjection nevertheless pleiotropic possess posterior rar reporter responsive responsiveness retinoid retinoids rxr selective striking vertebrate vertebrates xenopus xlim zebrafish
Tagcloud (Intersection) ?		introduced