HIST2H2AB and WDR77

Number of citations of the paper that reports this interaction (PMID 16712789)
13

Data Source:
BioGRID (pull down)

		HIST2H2AB	WDR77
Gene Name		histone cluster 2, H2ab	WD repeat domain 77
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Methylosome
	Molecular Function	Molecular_function DNA Binding Protein Heterodimerization Activity	Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
	Biological Process	Biological_process	Spliceosomal SnRNP Assembly Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Gene Expression NcRNA Metabolic Process Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Pathways		Chromatin modifying enzymes HDACs deacetylate histones Chromatin organization HATs acetylate histones RMTs methylate histone arginines	Chromatin modifying enzymes snRNP Assembly Chromatin organization Metabolism of non-coding RNA RMTs methylate histone arginines
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: APP EP300 WDR77	35 interactors: AQR BAG2 COPRS CTDP1 GPKOW HIST2H2AB HNRNPM LSM3 NKX3-1 PCBP2 PPIL1 PPP1R8 PQBP1 PRMT5 QKI RBM5 SAP30BP SF1 SF3A1 SF3B4 SMAD1 SMYD1 SNRPB SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SUZ12 THOC1 TOE1 YWHAB YWHAQ ZNF207
Entrez ID		317772	79084
HPRD ID		13659	14387
Ensembl ID		ENSG00000184270	ENSG00000116455
Uniprot IDs		Q8IUE6	B4DP38 Q9BQA1
PDB IDs			4GQB
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Regulation Of Protein Binding Histone H2B Acetylation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury N-terminal Peptidyl-lysine Acetylation Regulation Of Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Regulation Of Transcription From RNA Polymerase II Promoter Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Tubulin Deacetylation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition MRNA Processing Posttranscriptional Regulation Of Gene Expression Neuron Remodeling Positive Regulation By Host Of Viral Transcription N-terminal Protein Amino Acid Acetylation MRNA Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development RNA Processing Organ Development Epithelial Cell Differentiation Involved In Prostate Gland Development Cellular Copper Ion Homeostasis Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development RNA Metabolic Process Regulation Of Androgen Receptor Signaling Pathway Chromatin Organization Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Gene Expression Innate Immune Response N-terminal Protein Amino Acid Modification Neuron Maturation MRNA Polyadenylation Regulation Of Cellular Response To Heat Regulation Of Epidermal Growth Factor-activated Receptor Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Interaction With Symbiont Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus RNA Polyadenylation Neuron Recognition Apoptotic Process	RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing MRNA Metabolic Process Gene Expression RNA Metabolic Process Ribonucleoprotein Complex Assembly Spliceosomal SnRNP Assembly Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecular Complex Assembly Spliceosomal Complex Assembly Transcription, DNA-templated Histone MRNA Metabolic Process RNA Biosynthetic Process Cellular Metabolic Process Cellular Component Assembly NcRNA Metabolic Process Termination Of RNA Polymerase II Transcription DNA-templated Transcription, Termination MRNA 3'-end Processing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA 3'-end Processing MRNA 3'-splice Site Recognition Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Histone Methylation Regulation Of RNA Metabolic Process MRNA Splice Site Selection Biosynthetic Process Histone H4-R3 Methylation Protein Methylation Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Alternative MRNA Splicing, Via Spliceosome Histone Arginine Methylation Peptidyl-arginine Methylation Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of RNA Splicing Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?			androgen androgens ar ara70 ara70alpha ara70beta art benign coactivator coactivators corepressor cytoplasmic dysregulation ele1 exhibiting inhibitions internally luciferase mep50 ncoa4 p44 pca promotion spliced suppressive switch switches tblr1 versions
Tagcloud (Difference) ?			androgen androgens ar ara70 ara70alpha ara70beta art benign coactivator coactivators corepressor cytoplasmic dysregulation ele1 exhibiting inhibitions internally luciferase mep50 ncoa4 p44 pca promotion spliced suppressive switch switches tblr1 versions
Tagcloud (Intersection) ?