HLA-DOA

Description		major histocompatibility complex, class II, DO alpha
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Membrane Late Endosome Membrane MHC Class II Protein Complex
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of T Cell Differentiation Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation
Pathways		MHC class II antigen presentation
Drugs
Diseases
GWAS		Asthma ( 21804548 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Chronic hepatitis B infection ( 25802187) Lung cancer ( 28604730) Mortality in sepsis ( 27639821) Periodontitis (CDC/AAP) ( 24024966) Platelet count ( 22139419) Prostate cancer ( 29892016) Red wine liking ( 25758996) Systemic lupus erythematosus ( 32771030) Wegener's granulomatosis ( 23740775) White wine liking ( 25758996)
Interacting Genes		2 interacting genes: HLA-DMA REL
Entrez ID		3111
HPRD ID		00837
Ensembl ID		ENSG00000204252
Uniprot IDs		A0A1V0E3M7 A0A1V0E3N1 A0A1V0E3N3 A0A1V0E3N6 A0A1V0E3N7 A0A1V0E3P0 A0A1V0E3P1 A0A1V0E3P3 A0A1V0E3P6 A0A1V0E3P8 A0A1V0E3P9 A0A1V0E3Q1 A0A1V0E3Q2 A0A1V0E3Q3 A0A1V0E3Q4 A0A1V0E3Q5 A0A1V0E3Q6 A0A1V0E3Q7 A0A1V0E3Q8 A0A1V0E3R0 A0A1V0E3R3 A0A1V0E3R4 A0A1V0E3R6 A0A1V0E3R8 A0A1V0E3S0 A0A1V0E3S4 A0A1V0E3S6 A0A1V0E3S7 A0A1V0E3T1 P06340 X5CF87
PDB IDs		4I0P
Enriched GO Terms of Interacting Partners?		MHC Class II Protein Complex MHC Class II Protein Complex Binding Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Peptide Antigen Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Peptide Antigen Assembly With MHC Class II Protein Complex Negative Regulation Of Interferon-beta Production Non-canonical NF-kappaB Signal Transduction NF-kappaB Complex
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