GYPA and CLDN5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GYPA	CLDN5
Description		glycophorin A (MNS blood group)	claudin 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Membrane Ankyrin-1 Complex	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Paranode Region Of Axon Schmidt-Lanterman Incisure Tight Junction Anchoring Junction
	Molecular Function	Virus Receptor Activity Protein Binding Identical Protein Binding	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Symbiont Entry Into Host Cell	Outflow Tract Morphogenesis Cell-cell Junction Assembly Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Learning Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Maintenance Of Blood-brain Barrier Myelination Negative Regulation Of Vascular Permeability Response To Ethanol Roof Of Mouth Development Face Morphogenesis Bicellular Tight Junction Assembly Tight Junction Assembly Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Bicellular Tight Junction Assembly Establishment Of Blood-retinal Barrier
Pathways		Cell surface interactions at the vascular wall	Tight junction interactions RUNX1 regulates expression of components of tight junctions
Drugs
Diseases
GWAS		Adult body size ( 32376654) Bipolar disorder (body mass index interaction) ( 24322204) Blood pressure (smoking interaction) ( 25189868) Chronic obstructive pulmonary disease ( 25101718 30804561) Diabetic neuropathy in type 2 diabetes ( 33430853) Diastolic blood pressure ( 27841878) Femoral neck bone mineral density ( 30172743) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Lung function (low FEV1 vs high FEV1) ( 26423011) Major depressive disorder x sex interaction ( 34099189) Malaria ( 31844061) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Recurrent major depressive disorder x sex interaction ( 34099189) Red blood cell count ( 29403010) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Severe malaria ( 26416757) Systolic blood pressure ( 27841878) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White blood cell count ( 32888494)
Interacting Genes		24 interacting genes: ANKRD29 CLDN5 CREB3 ELOVL4 ERGIC3 EVA1A FAM209A FFAR2 GOLT1A GPRC5D GPX8 KEAP1 LAPTM5 PDZK1IP1 SAR1A SGTA SGTB SLC10A6 TLCD4 TMBIM6 TMEM14B TMEM154 TMEM237 TMEM31	40 interacting genes: AQP1 BTNL8 CCDC167 CLDN3 CLRN2 CNPY3 CORIN CTRL CXCL9 CYB561A3 EFNA5 EHHADH ERG28 ERMP1 FXYD6-FXYD2 GYPA LAT LHFPL5 MIP MPDZ PLP2 PLPPR2 PMP22 RPRM SFTPC SGCG SLC35B4 SMIM3 TECR TF TJP1 TMEM128 TMEM140 TMEM14C TMEM182 TMEM190 TMEM222 TSPAN2 VAMP5 YIPF1
Entrez ID		2993	7122
HPRD ID		07508	03654
Ensembl ID		ENSG00000170180	ENSG00000184113
Uniprot IDs		A0A2R8Y7F9 E9PD10 P02724 Q14419	D3DX19 O00501
PDB IDs		1AFO 2KPE 2KPF 5EH4 5EH6 7UZ3 7V07 7V0K 7V19 8CRQ 8CRR 8CRT 8CS9 8CSL 8CT3 8CTE
Enriched GO Terms of Interacting Partners?		Membrane TRC Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Negative Regulation Of Response To Endoplasmic Reticulum Stress Golgi Vesicle Transport Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway COPII Vesicle Coating	Membrane
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