WIF1 and ICOS

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		WIF1	ICOS
Gene Name		WNT inhibitory factor 1	inducible T-cell co-stimulator
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Protein Binding
	Biological Process	Signal Transduction Multicellular Organismal Development Wnt Signaling Pathway Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway	T Cell Tolerance Induction Immune Response Single Organismal Cell-cell Adhesion T Cell Costimulation
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Hippocampal volume ( 22504421)	Alopecia areata ( 20596022) Celiac disease ( 20190752) Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: ICOS KRTAP10-3 KRTAP10-8 RPL37	2 interactors: ICOSLG WIF1
Entrez ID		11197	29851
HPRD ID		05541	09196
Ensembl ID		ENSG00000156076	ENSG00000163600
Uniprot IDs		Q9Y5W5	Q53QY6 Q9Y6W8
PDB IDs		2D3J 2YGN 2YGO 2YGP 2YGQ
Enriched GO Terms of Interacting Partners?		T Cell Tolerance Induction Tolerance Induction
Tagcloud ?		aberrantly aom apcmin azoxymethane blt1 citrobacter coincided colonocytes crypt crypts deazaneplanocin dextran doi dss dznep epigenetically ezh2 f681y h3k27me3 hydroxamic knocked onc outbred paralleled polyps rodentium suberoylanilide swiss zeste	aberrant adaptive attributed b7 beneficial blockade blocking cd28 checkpoints combinatorial contributions ctla evasion exceptionally existing h4 immunity immunotherapies immunotherapy investigating microenvironment monotherapies pd prompting rely responsiveness restore substantial therapeutics
Tagcloud (Difference) ?		aberrantly aom apcmin azoxymethane blt1 citrobacter coincided colonocytes crypt crypts deazaneplanocin dextran doi dss dznep epigenetically ezh2 f681y h3k27me3 hydroxamic knocked onc outbred paralleled polyps rodentium suberoylanilide swiss zeste	aberrant adaptive attributed b7 beneficial blockade blocking cd28 checkpoints combinatorial contributions ctla evasion exceptionally existing h4 immunity immunotherapies immunotherapy investigating microenvironment monotherapies pd prompting rely responsiveness restore substantial therapeutics
Tagcloud (Intersection) ?