ABT1 and TSPYL2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ABT1	TSPYL2
Description		activator of basal transcription 1	TSPY like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Regulator Complex Nucleolus	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding	RDNA Binding Chromatin Binding Protein Binding Histone Binding
	Biological Process	Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage To Generate Mature 5'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Spinal Cord Motor Neuron Differentiation Small-subunit Processome Assembly Positive Regulation Of DNA-templated Transcription	Chromatin Organization Nucleosome Assembly Negative Regulation Of DNA Replication Regulation Of Signal Transduction Negative Regulation Of Cell Growth Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity
Pathways			XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		A body shape index ( 34021172) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) General cognitive ability ( 29844566) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Left-handedness ( 32989287) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Refractive error ( 32231278) Small cell lung carcinoma ( 28604730) Subcortical volume (MOSTest) ( 32665545) Waist circumference variance ( 31453325) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		16 interacting genes: APP CCDC136 CDCA7L CEP70 DVL3 EMD FAM9B LZTS2 MAB21L3 PICK1 PPP1CC PRNP RNF151 SYNE4 TBP TSPYL2	51 interacting genes: ABT1 AEBP2 APTX CASK CCNB1 CDK1 CDK2 CDK4 CEP19 COIL CREBBP CSNK2A1 DYRK1A EEF1A1 EZH2 GFI1B H2BC15 H3C1 HMGXB4 INO80B KDM6A KDM6B KMT5B LMO2 LNX1 MCRS1 NOL12 NOP53 PHF19 RBM15 RNF151 RPS25 SIRT6 SNIP1 TBC1D26 TMA16 TNNT1 TSPYL1 XAGE1A XAGE1B YAP1 ZBTB24 ZBTB48 ZFP1 ZNF280C ZNF286A ZNF329 ZNF524 ZNF687 ZNF775 ZNF835
Entrez ID		29777	64061
HPRD ID		16469	06713
Ensembl ID		ENSG00000146109	ENSG00000184205
Uniprot IDs		Q9ULW3	Q9H2G4
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuron Projection Organization Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Dendritic Spine Maintenance Intracellular Copper Ion Homeostasis Lamin Binding Regulation Of Protein Localization Copper Ion Homeostasis Cellular Response To Copper Ion Negative Regulation Of Canonical Wnt Signaling Pathway Molecular Function Activator Activity Positive Regulation Of Receptor Internalization Amyloid Fibril Formation Response To Copper Ion Negative Regulation Of Wnt Signaling Pathway Frizzled Binding Nuclear Outer Membrane Negative Regulation Of Fibroblast Proliferation Dendritic Spine Organization Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium Reproductive Process Regulation Of Response To Calcium Ion Regulation Of Synaptic Plasticity Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation TMEM240-body Male Gamete Generation Spermatogenesis Type 8 Metabotropic Glutamate Receptor Binding Postsynapse Organization Primary Ureteric Bud Growth Developmental Process Involved In Reproduction Cellular Response To Amyloid-beta Regulation Of Amyloid Precursor Protein Catabolic Process Postsynapse Regulation Of Establishment Of Protein Localization Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Receptor-mediated Endocytosis Cytoplasm Gamete Generation Regulation Of Canonical Wnt Signaling Pathway Response To Amyloid-beta Glial Cell Development Acetylcholine Receptor Activator Activity Positive Regulation Of Neuron Apoptotic Process Lipoprotein Particle	Nucleus Chromatin Organization Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Nucleolus Regulation Of Primary Metabolic Process Regulation Of Metabolic Process DNA Repair RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA Metabolic Process Chromatin Binding Zinc Ion Binding DNA Damage Response G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Chromatin DNA Binding Transcription Regulator Complex Cyclin B1-CDK1 Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process ESC/E(Z) Complex Positive Regulation Of Chromosome Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of DNA Metabolic Process Cyclin-dependent Protein Kinase Activity Regulation Of Cell Cycle G2/M Phase Transition Metal Ion Binding Cellular Response To Stress Telomere Organization Positive Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Histone H3K27me2/H3K27me3 Demethylase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of DNA Repair Protein Localization To Site Of Double-strand Break Regulation Of DNA Repair Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Cardiac Muscle Cell Proliferation Cyclin-dependent Protein Serine/threonine Kinase Activity
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