TMOD3 and TNFSF11

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TMOD3	TNFSF11
Gene Name		tropomodulin 3 (ubiquitous)	tumor necrosis factor (ligand) superfamily, member 11
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Striated Muscle Thin Filament	Extracellular Region Extracellular Space Cytoplasm Integral Component Of Plasma Membrane
	Molecular Function	Actin Binding Tropomyosin Binding	Cytokine Activity Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor Receptor Superfamily Binding
	Biological Process	Muscle Contraction Actin Filament Organization Myofibril Assembly Erythrocyte Development Pointed-end Actin Filament Capping Positive Regulation Of Mitotic Cell Cycle Phase Transition	Ossification Osteoclast Proliferation Monocyte Chemotaxis Immune Response Activation Of JUN Kinase Activity Organ Morphogenesis Cytokine-mediated Signaling Pathway Osteoclast Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Bone Resorption Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of T Cell Activation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Positive Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Protein Kinase B Signaling Calcium Ion Homeostasis Mammary Gland Alveolus Development ERK1 And ERK2 Cascade Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion TNFSF11-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Osteoclast Development
Pathways
Drugs
Diseases
GWAS			Bone mineral density ( 23437003) Cortical thickness ( 22792071) Crohn's disease ( 21102463)
Protein-Protein Interactions		4 interactors: CSNK2A1 DUSP23 MAP1LC3B TNFSF11	31 interactors: ADAM17 ADAM19 AKT1 BBS10 DDAH2 EEF1A1 EZH2 FAM213B KHDRBS1 KIAA1377 LMO4 MAPK1 MAPK3 MAPK8 MBTPS1 MED24 MMP1 MMP3 MMP7 NFKB1 NFKBIA PHAX PLK1 SBF1 SNRNP35 TMOD3 TNFRSF11A TNFRSF11B TRAF6 TRMT2A ZC3HC1
Entrez ID		29766	8600
HPRD ID		10389	04031
Ensembl ID		ENSG00000138594	ENSG00000120659
Uniprot IDs		Q9NYL9	O14788 Q54A98 Q5T9Y4
PDB IDs			3URF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Corticotropin-releasing Hormone Secretion Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling TNFSF11-mediated Signaling Pathway Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Osteoclast Development Osteoclast Proliferation Regulation Of Osteoclast Development Positive Regulation Of Fever Generation Response To External Stimulus Regulation Of Fever Generation Positive Regulation Of Heat Generation Positive Regulation Of Prostaglandin Secretion Monocyte Chemotaxis Positive Regulation Of Bone Resorption Cellular Response To Nitrogen Starvation ERK1 And ERK2 Cascade Positive Regulation Of Icosanoid Secretion Nucleophagy Chemotaxis Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Fatty Acid Transport Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Acute Inflammatory Response Mitochondrion Degradation Positive Regulation Of Tissue Remodeling Regulation Of Fatty Acid Transport Regulation Of Bone Resorption Bone Resorption Tumor Necrosis Factor-mediated Signaling Pathway Organelle Disassembly Phosphate-containing Compound Metabolic Process Mitotic Spindle Checkpoint Activation Of JUN Kinase Activity Negative Regulation Of Chromosome Segregation Autophagic Vacuole Assembly Mammary Gland Lobule Development Regulation Of Bone Remodeling Mammary Gland Alveolus Development Osteoclast Differentiation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division	Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Neurotrophin Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Membrane Protein Proteolysis Toll-like Receptor 4 Signaling Pathway Response To Lipopolysaccharide Toll-like Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Bacterium Membrane Protein Intracellular Domain Proteolysis Response To Molecule Of Bacterial Origin Fc-epsilon Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Transferase Activity Activation Of Innate Immune Response Cellular Response To Growth Factor Stimulus Cellular Response To Lipopolysaccharide Response To Growth Factor Response To Epidermal Growth Factor Fc Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Response To Other Organism Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Biotic Stimulus Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Cell Death Death Regulation Of Innate Immune Response
Tagcloud ?			actors apatite autophagic autophagy calcified corals crystals extend favoring mechanosensing mineralization mineralized mineralizing multifunctional nfkb1 ob oc osteoblasts osteocytes osteoporosis pathologies resorption secrete specialized trabecular uncover vacuoles vehicles vertebrates
Tagcloud (Difference) ?			actors apatite autophagic autophagy calcified corals crystals extend favoring mechanosensing mineralization mineralized mineralizing multifunctional nfkb1 ob oc osteoblasts osteocytes osteoporosis pathologies resorption secrete specialized trabecular uncover vacuoles vehicles vertebrates
Tagcloud (Intersection) ?