GTF2H2 and CYP26B1

		GTF2H2	CYP26B1
Description		general transcription factor IIH subunit 2	cytochrome P450 family 26 subfamily B member 1
Image			No pdb structure
GO Annotations	Cellular Component	Core TFIIH Complex Portion Of Holo TFIIH Complex Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Nuclear Speck	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Zinc Ion Binding RNA Polymerase II General Transcription Initiation Factor Activity Metal Ion Binding	Retinoic Acid Binding Monooxygenase Activity Iron Ion Binding Protein Binding Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Metal Ion Binding All-trans Retinoic Acid 18-hydroxylase Activity
	Biological Process	G Protein-coupled Receptor Internalization DNA Repair Nucleotide-excision Repair DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter DNA Damage Response Response To UV	Cell Fate Determination Establishment Of T Cell Polarity Kidney Development Lipid Metabolic Process Vitamin Metabolic Process Xenobiotic Metabolic Process Inflammatory Response Male Meiotic Nuclear Division Spermatogenesis Central Nervous System Development Proximal/distal Pattern Formation Positive Regulation Of Gene Expression Embryonic Limb Morphogenesis Response To Retinoic Acid Response To Vitamin A Retinoic Acid Catabolic Process Retinoic Acid Metabolic Process Tongue Morphogenesis Regulation Of T Cell Differentiation Retinoic Acid Receptor Signaling Pathway Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Bone Morphogenesis Establishment Of Skin Barrier Cornification Cellular Response To Retinoic Acid Positive Regulation Of Tongue Muscle Cell Differentiation
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE	Vitamins RA biosynthesis pathway Defective CYP26B1 causes RHFCA
Drugs			Tretinoin
Diseases
GWAS			Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Heel bone mineral density ( 30598549) Height ( 31562340) IgA levels ( 28628107) Malaria ( 31844061) Mitochondrial heteroplasmy measurement ( 33731350) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Schizophrenia ( 25056061) Serum metabolite levels ( 33031748)
Interacting Genes		11 interacting genes: AR CDK7 DNMT3L ERCC2 ERCC3 ERCC8 ERRFI1 GTF2E1 GTF2H1 GTF2H5 SRA1	1 interacting genes: NEDD4L
Entrez ID		2966	56603
HPRD ID		03450	05550
Ensembl ID		ENSG00000145736	ENSG00000003137
Uniprot IDs		Q13888	E7ER08 Q9NR63
PDB IDs		1Z60 5IVW 5IY6 5IY7 5IY8 5IY9 5O85 5OF4 6NMI 6O9L 6O9M 6RO4 7AD8 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Transcription Initiation At RNA Polymerase II Promoter DNA-templated Transcription Initiation Nucleotide-excision Repair Transcription By RNA Polymerase II Transcription Factor TFIID Complex DNA-templated Transcription DNA-templated Transcription Elongation Transcription-coupled Nucleotide-excision Repair DNA Repair Nucleobase-containing Compound Biosynthetic Process RNA Metabolic Process Nucleic Acid Metabolic Process Macromolecule Biosynthetic Process CAK-ERCC2 Complex Hormone-mediated Signaling Pathway DNA Metabolic Process Transcription Elongation By RNA Polymerase I DNA Damage Response Nucleobase-containing Compound Metabolic Process UV Protection Nucleoplasm Nuclear Receptor-mediated Signaling Pathway Nucleus Cellular Response To Stress Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Hair Cell Differentiation Response To UV Response To Radiation Insulin-like Growth Factor Receptor Signaling Pathway Animal Organ Development Macromolecule Metabolic Process DNA Helicase Activity Cell Death Maturation Of SSU-rRNA Programmed Cell Death Transcription Elongation By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Prostate Induction Intracellular Receptor Signaling Pathway Male Somatic Sex Determination RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity Response To Stress Regulation Of Transcription-coupled Nucleotide-excision Repair Skin Development Positive Regulation Of Mitotic Recombination Nucleotide-excision Repair Factor 3 Complex Male Meiotic Nuclear Division Nucleotide-excision Repair, Preincision Complex Assembly	Receptor Internalization Prenylcysteine Oxidase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Oxygen As Acceptor Prenylcysteine Catabolic Process Farnesylcysteine Lyase Activity Prenylated Protein Catabolic Process Receptor-mediated Endocytosis Core TFIIH Complex Portion Of Holo TFIIH Complex Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Caveolin-mediated Endocytosis Enucleate Erythrocyte Differentiation Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Potassium Ion Export Across Plasma Membrane Sodium Channel Inhibitor Activity
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