CYP26B1

Gene Name		cytochrome P450, family 26, subfamily B, polypeptide 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane
	Molecular Function	Retinoic Acid Binding Iron Ion Binding Retinoic Acid 4-hydroxylase Activity Heme Binding
	Biological Process	Cell Fate Determination Vitamin Metabolic Process Xenobiotic Metabolic Process Male Meiosis Spermatogenesis Proximal/distal Pattern Formation Positive Regulation Of Gene Expression Embryonic Limb Morphogenesis Retinoic Acid Catabolic Process Tongue Morphogenesis Small Molecule Metabolic Process Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Oxidation-reduction Process Bone Morphogenesis Establishment Of Skin Barrier Cornification Cellular Response To Retinoic Acid Positive Regulation Of Tongue Muscle Cell Differentiation
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Biological oxidations RA biosynthesis pathway Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Signaling by Retinoic Acid Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Vitamins Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: NEDD4L
Entrez ID		56603
HPRD ID		05550
Ensembl ID		ENSG00000003137
Uniprot IDs		Q9NR63
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Protein Localization To Cell Surface Regulation Of Tight Junction Assembly Negative Regulation Of Sodium Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Sodium Ion Homeostasis Ventricular Cardiac Muscle Cell Action Potential Regulation Of Protein Localization To Cell Surface Negative Regulation Of Potassium Ion Transport Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Membrane Repolarization Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Sodium Ion Homeostasis Regulation Of Potassium Ion Transmembrane Transporter Activity Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cation Channel Activity Positive Regulation Of Sodium Ion Transport Cardiac Muscle Cell Action Potential Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Membrane Depolarization Regulation Of Sodium Ion Transmembrane Transport Response To Salt Stress Protein K48-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Transporter Activity Protein Monoubiquitination Regulation Of Cardiac Muscle Cell Contraction Excretion Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Blood Pressure Positive Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Transmembrane Transport Positive Regulation Of Transporter Activity Regulation Of Cell Junction Assembly Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Potassium Ion Transport Water Homeostasis Regulation Of Sodium Ion Transport Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cardiac Muscle Contraction Positive Regulation Of Ion Transmembrane Transport Regulation Of Cation Channel Activity Regulation Of Striated Muscle Contraction Action Potential Response To Osmotic Stress
Tagcloud ?		atra broadly circadian circuitry cytochromes degrading diminish dynamically learned lman magnocellular morphogenetic natally nidopallium obligatory refined retinoid song songbirds spatially synthesizing telencephalic underlies underscores vertebrate vocalizations zraldh