GTF2H5 and NGRN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GTF2H5	NGRN
Description		general transcription factor IIH subunit 5	neugrin, neurite outgrowth associated
Image			No pdb structure
GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Nucleolus Cytoplasm	Extracellular Region Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Membrane Nuclear Body Mitochondrial Membrane Intercellular Bridge Mitotic Spindle
	Molecular Function	Protein Binding	RNA Binding Protein Binding RRNA Binding
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) DNA Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Assembly Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter DNA Damage Response Cellular Response To Gamma Radiation	Cell Differentiation Neuron Differentiation Mitochondrial Ribosome Assembly Positive Regulation Of Mitochondrial Translation
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE	rRNA modification in the mitochondrion Mitochondrial mRNA modification
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Lipoprotein (a) levels ( 26377243) Plasma anti-thyroglobulin levels ( 29678681) Systemic sclerosis ( 29293537)	Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725) Multiple sclerosis ( 31604244)
Interacting Genes		8 interacting genes: ANKRD29 CDK7 ERCC3 GSC2 GTF2E1 GTF2H2 INCA1 NGRN	6 interacting genes: DNMT1 GTF2H5 PRKAG3 SHANK3 TSC22D2 YOD1
Entrez ID		404672	51335
HPRD ID		10581	14825
Ensembl ID		ENSG00000272047	ENSG00000182768
Uniprot IDs		Q6ZYL4	Q9NPE2
PDB IDs		1YDL 2JNJ 5IVW 5IY6 5IY7 5IY8 5IY9 5OF4 6NMI 6O9L 6O9M 6RO4 7AD8 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVV 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Transcription Initiation At RNA Polymerase II Promoter Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex DNA-templated Transcription Initiation Transcription Factor TFIID Complex Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase II General Transcription Initiation Factor Activity Transcription Elongation By RNA Polymerase II DNA-templated Transcription Elongation Nucleotide-excision Repair Nucleobase-containing Compound Biosynthetic Process RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity Nucleotide-excision Repair Factor 3 Complex Transcription Factor TFIIE Complex DNA Repair Transcription Factor TFIIK Complex Core TFIIH Complex Portion Of Holo TFIIH Complex CAK-ERCC2 Complex Transcription Pausing By RNA Polymerase II RNA Metabolic Process Response To UV Nucleoplasm Macromolecule Biosynthetic Process Mitochondrial Ribosome Assembly RNA Polymerase II Promoter Clearance DNA Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity DNA Damage Response SnRNA Transcription By RNA Polymerase II DNA Topological Change Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleus Negative Regulation Of Cyclin-dependent Protein Kinase Activity UV Protection Transcription-coupled Nucleotide-excision Repair 3'-5' DNA Helicase Activity Transcription Preinitiation Complex Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity SnRNA Transcription G Protein-coupled Receptor Internalization Positive Regulation Of Mitochondrial Translation DNA Conformation Change Nucleic Acid Metabolic Process Response To Light Stimulus Regulation Of Mitochondrial Translation Ribosome Assembly	Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching DNA-methyltransferase Activity Chromosomal DNA Methylation Maintenance Following DNA Replication Regulation Of Phenotypic Switching Germ Cell Nucleus Cellular Response To Bisphenol A DNA (cytosine-5-)-methyltransferase Activity Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Regulation Of Carbon Utilization Protein K33-linked Deubiquitination Protein K29-linked Deubiquitination Protein K27-linked Deubiquitination Guanylate Kinase-associated Protein Clustering Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity Positive Regulation Of Synapse Structural Plasticity NMDA Glutamate Receptor Clustering Striatal Medium Spiny Neuron Differentiation Nucleotide-excision Repair, Preincision Complex Assembly Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Response To Bisphenol A AMP-activated Protein Kinase Activity Postsynaptic Density Assembly Regulation Of Synapse Structural Plasticity Transcription Elongation By RNA Polymerase I Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Nucleotide-activated Protein Kinase Complex Negative Regulation Of Glycogen Biosynthetic Process AMP Binding Negative Regulation Of Protein Exit From Endoplasmic Reticulum Protein K11-linked Deubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Vocal Learning Positive Regulation Of Glutamate Receptor Signaling Pathway Neuron Spine Positive Regulation Of Long-term Neuronal Synaptic Plasticity GABAergic Neuron Differentiation Regulation Of Glutamate Receptor Signaling Pathway Observational Learning Postsynaptic Specialization Assembly Transcription Factor TFIIH Core Complex Female Germ Cell Nucleus Regulation Of Retrograde Protein Transport, ER To Cytosol Neurotransmitter-gated Ion Channel Clustering Transcription Factor TFIIH Holo Complex Auditory Behavior Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Long-term Synaptic Depression Protein Kinase Regulator Activity
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