GSK3A and GSKIP

Number of citations of the paper that reports this interaction (PMID 20368287)
12

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		GSK3A	GSKIP
Gene Name		glycogen synthase kinase 3 alpha	GSK3B interacting protein
Image
Gene Ontology Annotations	Cellular Component	Cytosol Beta-catenin Destruction Complex	Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase A Catalytic Subunit Binding Tau-protein Kinase Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Cardiac Left Ventricle Morphogenesis Glycogen Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Protein Phosphorylation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of UDP-glucose Catabolic Process Wnt Signaling Pathway Cell Migration Positive Regulation Of CAMP Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of TOR Signaling Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interleukin-3 Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Hypermethylation Of CpG Island Cellular Protein Metabolic Process Innate Immune Response Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Heart Contraction Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Negative Regulation Of Transferase Activity Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Lithium Ion Cellular Response To Organic Cyclic Compound Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Glycogen (starch) Synthase Activity
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer XBP1(S) activates chaperone genes Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) IRE1alpha activates chaperones PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Unfolded Protein Response (UPR) Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: AKT1 BCL3 BICD1 CREB1 CREM DEAF1 EBNA1BP2 EIF2B5 FAM193B GLI3 GSKIP HSF1 LRSAM1 MAPT MCL1 MYC NBR1 PRKACA PRKCA PRKCB PRKCD PRKCG PRKCH PRKCZ PRKD3 PRKDC PXN SGK1 SGK3 SPG21 YWHAG	3 interactors: EXT2 GSK3A PEX19
Entrez ID		2931	51527
HPRD ID		06002	16601
Ensembl ID		ENSG00000105723	ENSG00000100744
Uniprot IDs		P49840	Q9P0R6
PDB IDs		2DFM	1SGO
Enriched GO Terms of Interacting Partners?		Response To Stress Protein Phosphorylation Regulation Of Phospholipase Activity Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Phosphorylation Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Platelet Activation Cell Death Death Positive Regulation Of Phospholipase Activity Cell Activation Negative Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Lipase Activity Intracellular Signal Transduction Regulation Of Cell Death Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Histone H3-T6 Phosphorylation Negative Regulation Of Apoptotic Process Activation Of Phospholipase C Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Phospholipase C Activity Negative Regulation Of Cell Death Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Phosphorylation Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Response To Organonitrogen Compound Developmental Process Response To Growth Factor Phosphate-containing Compound Metabolic Process Wound Healing Regulation Of Cellular Response To Insulin Stimulus Blood Coagulation Hemostasis Response To Peptide Hormone Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process	Polysaccharide Metabolic Process Negative Regulation Of UDP-glucose Catabolic Process Negative Regulation Of Lipid Binding Negative Regulation Of Type B Pancreatic Cell Development Cellular Carbohydrate Metabolic Process Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Positive Regulation Of Adrenergic Receptor Signaling Pathway Hypermethylation Of CpG Island Peroxisome Membrane Biogenesis Cellular Response To Interleukin-3 Positive Regulation Of Glycogen (starch) Synthase Activity Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Protein Import Into Peroxisome Membrane Chaperone-mediated Protein Transport Peroxisomal Membrane Transport Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Glucose Import Peroxisome Fission Regulation Of Type B Pancreatic Cell Development Cardiac Left Ventricle Morphogenesis Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Glucose Transport Cellular Response To Lithium Ion Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of DNA Methylation Negative Regulation Of Cardiac Muscle Tissue Development Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Heparan Sulfate Proteoglycan Biosynthetic Process Membrane Biogenesis Regulation Of Gene Expression By Genetic Imprinting Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Heart Contraction Response To Lithium Ion Regulation Of Cardiac Muscle Hypertrophy Regulation Of Glycogen Biosynthetic Process Negative Regulation Of TOR Signaling Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Heparan Sulfate Proteoglycan Metabolic Process Genetic Imprinting Negative Regulation Of Epithelial Cell Differentiation Negative Regulation Of Organ Growth
Tagcloud ?		2h 4e accelerated bp1 carboxymethoxyphenyl deacetylase dimethylthiazol ezh2 glioma gliomas glycogen incubated mts p70 p70s6k pci phosphatidylinositol promotes razolium s6 simulated sirna sulfophenyl suppresses suppressing tet yl zeste	altogether axons cadherin catenin characterize dendrites depletion differentiate downregulates emerging gsk3beta inhibiting interfering interplay negatively neurite neuroblastoma neuron outgrowth pivotal pool prevents propose raises ser396 sh specification sy5y wnt
Tagcloud (Difference) ?		2h 4e accelerated bp1 carboxymethoxyphenyl deacetylase dimethylthiazol ezh2 glioma gliomas glycogen incubated mts p70 p70s6k pci phosphatidylinositol promotes razolium s6 simulated sirna sulfophenyl suppresses suppressing tet yl zeste	altogether axons cadherin catenin characterize dendrites depletion differentiate downregulates emerging gsk3beta inhibiting interfering interplay negatively neurite neuroblastoma neuron outgrowth pivotal pool prevents propose raises ser396 sh specification sy5y wnt
Tagcloud (Intersection) ?