ERP27 and C12orf60

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ERP27	C12orf60
Description		endoplasmic reticulum protein 27	chromosome 12 open reading frame 60
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding	Protein Binding
	Biological Process	Protein Folding Response To Unfolded Protein Response To Endoplasmic Reticulum Stress
Pathways
Drugs
Diseases
GWAS		Finger osteoarthritis severity (hand Klsum) ( 33055079) Hand grip strength ( 29313844) Hand osteoarthritis severity (hand Klsum) ( 33055079) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Osteoarthritis of the hand ( 28855172)	Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Pubertal anthropometrics ( 23449627)
Interacting Genes		10 interacting genes: BLOC1S2 C12orf60 GOLGA8F MED20 PDIA3 SGTA UBL4A UBQLN1 UBQLN2 UBQLN4	1 interacting genes: ERP27
Entrez ID		121506	144608
HPRD ID		08723	11358
Ensembl ID		ENSG00000139055	ENSG00000182993
Uniprot IDs		F5GYS6 Q96DN0	Q5U649
PDB IDs		2L4C 4F9Z
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Response To Endoplasmic Reticulum Stress Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Targeting To ER Protein Insertion Into ER Membrane Macromolecule Catabolic Process Regulation Of Cellular Response To Stress Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Macroautophagy Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Autophagy Negative Regulation Of Store-operated Calcium Channel Activity Protein Targeting To Membrane Protein Insertion Into Membrane Cellular Response To Stress Tapasin-ERp57 Complex TRC Complex Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Autophagy Nuclear Proteasome Complex Autophagosome Assembly Autophagosome Organization BAT3 Complex Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Identical Protein Binding Extrinsic Apoptotic Signaling Pathway Proteasomal Protein Catabolic Process BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Catabolic Process Cytosolic Proteasome Complex Positive Regulation Of Catabolic Process	Protein Disulfide Isomerase Activity Response To Unfolded Protein Protein Folding Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Lumen
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