USP50

Description		ubiquitin specific peptidase 50
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Postsynaptic Density Midbody
	Molecular Function	Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin-like Protein Peptidase Activity
	Biological Process	Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Nuclear Speck Organization Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Cell Cycle G2/M Phase Transition
Pathways
Drugs
Diseases
GWAS		Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Myeloid white cell count ( 27863252) QT interval ( 24952745) Refractive error ( 32231278) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		5 interacting genes: ACE2 AKT1 HSP90AA1 HSP90AB1 PYCARD
Entrez ID		373509
HPRD ID		15639
Ensembl ID		ENSG00000170236
Uniprot IDs		Q70EL3
PDB IDs
Enriched GO Terms of Interacting Partners?		Nitric-oxide Synthase Regulator Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Telomerase Holoenzyme Complex Assembly Response To Heat Dendritic Growth Cone TPR Domain Binding Positive Regulation Of Cardiac Muscle Contraction Positive Regulation Of Cellular Component Biogenesis Secretory Granule Lumen Virion Attachment To Host Cell Adhesion Of Symbiont To Host Cell Positive Regulation Of Striated Muscle Contraction Adhesion Of Symbiont To Host Response To Temperature Stimulus Regulation Of Protein Modification Process Identical Protein Binding Positive Regulation Of Protein Localization To Cell Surface Regulation Of Protein Ubiquitination Protein Homodimerization Activity Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding Activation Of Innate Immune Response Protein-containing Complex Axonal Growth Cone RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Regulation Of Defense Response Positive Regulation Of Transport Regulation Of Post-translational Protein Modification Nitric Oxide Metabolic Process Telomere Maintenance Via Telomere Lengthening Reactive Nitrogen Species Metabolic Process Maternal Process Involved In Female Pregnancy Positive Regulation Of Defense Response To Virus By Host Protein Folding Chaperone Complex ATP-dependent Protein Folding Chaperone Positive Regulation Of Heart Contraction Regulation Of Protein Localization To Cell Surface Positive Regulation Of Innate Immune Response Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Defense Response To Virus By Host Tau Protein Binding Regulation Of Biological Quality Positive Regulation Of Cellular Component Organization Positive Regulation Of Muscle Contraction
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