SSU72 and RAD21

Number of citations of the paper that reports this interaction (PubMedID 20818333)
32

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		SSU72	RAD21
Description		SSU72 homolog, RNA polymerase II CTD phosphatase	RAD21 cohesin complex component
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex	Chromosome, Centromeric Region Chromatin Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cytoskeleton Cohesin Complex Membrane Nuclear Matrix Midbody Mitotic Cohesin Complex Meiotic Cohesin Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Hydrolase Activity	Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding LncRNA Binding DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Termination Of RNA Polymerase II Transcription MRNA Processing MRNA 3'-end Processing Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway	Response To Hypoxia DNA Repair Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Chromosome Segregation Sister Chromatid Cohesion Reciprocal Meiotic Recombination Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Establishment Of Mitotic Sister Chromatid Cohesion Establishment Of Meiotic Sister Chromatid Cohesion Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin Chromatin Looping Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Pathways		RNA polymerase II transcribes snRNA genes	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Menopause (age at onset) ( 29773799)
Interacting Genes		4 interacting genes: MAPK8 MAPK9 RAD21 STAG2	30 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B PTEN RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 SUMO2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80
Entrez ID		29101	5885
HPRD ID		13712	05924
Ensembl ID		ENSG00000160075	ENSG00000164754
Uniprot IDs		Q9NP77	O60216
PDB IDs		3O2Q 3O2S 4H3H 4H3K	4PJU 4PJW 4PK7 6QNX 6RRC 6RRK 6WG3 6WGE 7W1M 7ZJS 8K4D 8P0A 8PQ5 8RO6 8RO7 8RO8 8RO9 8ROA 8ROB 8ROC 8ROD 8ROE 8ROF 8ROG 8ROH 8ROI 8ROJ 8ROK 8ROL
Enriched GO Terms of Interacting Partners?		JUN Kinase Activity Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Establishment Of Sister Chromatid Cohesion MAP Kinase Activity Fc-epsilon Receptor Signaling Pathway Sister Chromatid Cohesion Fc Receptor Signaling Pathway JNK Cascade Cellular Senescence Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Protein Localization To Chromosome JUN Phosphorylation Cellular Response To Reactive Oxygen Species Regulation Of Circadian Rhythm Protein Localization To Tricellular Tight Junction Nuclear Matrix Chromosome Segregation Positive Regulation Of MRNA Metabolic Process Response To Reactive Oxygen Species Establishment Of Meiotic Sister Chromatid Cohesion Chromosome, Centromeric Region Cellular Response To Oxygen-containing Compound Intracellular Signaling Cassette Regulation Of MRNA Stability Positive Regulation Of Protein-containing Complex Assembly Regulation Of RNA Stability Histone Deacetylase Regulator Activity Cellular Response To Oxidative Stress Basal Dendrite Meiotic Cohesin Complex Double-strand Break Repair Replication-born Double-strand Break Repair Via Sister Chromatid Exchange MAPK Cascade Rhythmic Process Cellular Response To Chemical Stress Positive Regulation Of Cellular Component Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Sister Chromatid Cohesion Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cytosol Positive Regulation Of Gene Expression Positive Regulation Of Podosome Assembly Regulation Of MRNA Metabolic Process Inflammatory Response To Wounding	Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Establishment Of Sister Chromatid Cohesion Mitotic Spindle Pole Spindle Assembly Microtubule Cytoskeleton Organization Nuclear Matrix Microtubule Cytoskeleton Organization Involved In Mitosis Cytoskeleton Organization Chromosome Segregation Spindle Organization Cytosol Microtubule-based Process Sister Chromatid Cohesion Mitotic Spindle Assembly Negative Regulation Of Cell Size Membraneless Organelle Assembly Cell Division Establishment Of Spindle Localization Cytosolic Large Ribosomal Subunit RNA Binding Spindle Localization Chromosome, Centromeric Region Negative Regulation Of PERK-mediated Unfolded Protein Response Protein Phosphatase Type 1 Complex Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Cell Size Positive Regulation Of Proteolysis Actin Binding Regulation Of Proteolysis Mitotic Spindle Organization Cytosolic Ribosome Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ficolin-1-rich Granule Lumen Cofilin-actin Rod Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Regulation Of Cellular Component Size Positive Regulation Of Barbed-end Actin Filament Capping Regulation Of Cell-matrix Adhesion Positive Regulation Of Protein Localization To Cell Leading Edge Cortical Microtubule Meiotic Cell Cycle Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Chromosome Organelle Assembly
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