SSU72 and MAPK9

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SSU72	MAPK9
Description		SSU72 homolog, RNA polymerase II CTD phosphatase	mitogen-activated protein kinase 9
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Nuclear Speck Schaffer Collateral - CA1 Synapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Hydrolase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Termination Of RNA Polymerase II Transcription MRNA Processing MRNA 3'-end Processing Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway	MAPK Cascade Protein Phosphorylation JNK Cascade Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Reactive Oxygen Species Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Regulation Of MRNA Stability Response To Cadmium Ion Rhythmic Process Modulation Of Chemical Synaptic Transmission MRNA Destabilization Protein Localization To Tricellular Tight Junction Positive Regulation Of Podosome Assembly Cellular Senescence Inflammatory Response To Wounding Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Apoptotic Signaling Pathway
Pathways		RNA polymerase II transcribes snRNA genes	Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors Signaling by ALK fusions and activated point mutants
Drugs			Minocycline N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide Fostamatinib Halicin
Diseases
GWAS		Body mass index ( 26426971)	Appendicular lean mass ( 33097823) Blood protein levels ( 30072576)
Interacting Genes		4 interacting genes: MAPK8 MAPK9 RAD21 STAG2	111 interacting genes: ACP5 AKT1 ARRB1 ARRB2 ATF2 ATF7 BCL2L1 BCL2L11 BTRC C1orf105 C1orf94 CASP3 CBLL2 CCDC33 CDC16 CDC25B CDC25C CEP126 CEP44 CLU CTBP1 CTNNB1 DCX DTX3 DUSP10 DUSP16 DUSP19 DUSP4 EEF2K EFHC2 EGFR ELK1 ELK3 ENKD1 FBXO7 GFAP GOLGA6A GRB2 GSC2 H3-3A HDAC9 HSF1 IHO1 IRS1 ITGB3BP JDP2 JUN JUNB JUND KLHL8 KPNA3 L3MBTL3 LHX3 LMAN2 LNX1 LNX2 LZTS1 MACF1 MAP2K4 MAP2K7 MAP3K1 MAP3K10 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAPK5 MAPKBP1 MAPT MCRS1 MED12L MEOX1 MLIP NCF1 NCSTN NFATC3 NFATC4 NHSL2 PAX5 PBX4 PICK1 POU6F2 PPARG PRKD1 PSEN1 RB1 RPS6KB1 RSPO4 SAXO1 SDCBP SF3B4 SH3BP5 SHMT1 SMAD2 SMAD3 SMCO3 SSU72 TCP10L TEX11 TOB1 TP53 TRAF2 TUSC2 WDR62 XPNPEP1 XPO7 ZBTB25 ZC2HC1C ZFTRAF1 ZNF138 ZNF559 ZNHIT1
Entrez ID		29101	5601
HPRD ID		13712	04206
Ensembl ID		ENSG00000160075	ENSG00000050748
Uniprot IDs		Q9NP77	D7R525 P45984
PDB IDs		3O2Q 3O2S 4H3H 4H3K	3E7O 3NPC 7CML 7N8T 8ELC
Enriched GO Terms of Interacting Partners?		JUN Kinase Activity Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Establishment Of Sister Chromatid Cohesion MAP Kinase Activity Fc-epsilon Receptor Signaling Pathway Sister Chromatid Cohesion Fc Receptor Signaling Pathway JNK Cascade Cellular Senescence Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Protein Localization To Chromosome JUN Phosphorylation Cellular Response To Reactive Oxygen Species Regulation Of Circadian Rhythm Protein Localization To Tricellular Tight Junction Nuclear Matrix Chromosome Segregation Positive Regulation Of MRNA Metabolic Process Response To Reactive Oxygen Species Establishment Of Meiotic Sister Chromatid Cohesion Chromosome, Centromeric Region Cellular Response To Oxygen-containing Compound Intracellular Signaling Cassette Regulation Of MRNA Stability Positive Regulation Of Protein-containing Complex Assembly Regulation Of RNA Stability Histone Deacetylase Regulator Activity Cellular Response To Oxidative Stress Basal Dendrite Meiotic Cohesin Complex Double-strand Break Repair Replication-born Double-strand Break Repair Via Sister Chromatid Exchange MAPK Cascade Rhythmic Process Cellular Response To Chemical Stress Positive Regulation Of Cellular Component Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Sister Chromatid Cohesion Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cytosol Positive Regulation Of Gene Expression Positive Regulation Of Podosome Assembly Regulation Of MRNA Metabolic Process Inflammatory Response To Wounding	Intracellular Signaling Cassette Intracellular Signal Transduction MAPK Cascade Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Protein Kinase Binding Cellular Developmental Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway Nucleus Positive Regulation Of Transcription By RNA Polymerase II JNK Cascade JUN Kinase Binding Programmed Cell Death Cell Death Negative Regulation Of Apoptotic Process Cytoplasm Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Protein Binding Negative Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process
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