STXBP6 and SNAP25

Number of citations of the paper that reports this interaction (PubMedID 12145319)
0

Data Source:
HPRD (in vitro, in vivo)

		STXBP6	SNAP25
Description		syntaxin binding protein 6	synaptosome associated protein 25
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Adherens Junction Membrane	Photoreceptor Inner Segment Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Cell Cortex Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Axon Growth Cone BLOC-1 Complex SNARE Complex Vesicle Specific Granule Membrane Somatodendritic Compartment Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Tertiary Granule Membrane Ribbon Synapse Glutamatergic Synapse
	Molecular Function	Cadherin Binding Involved In Cell-cell Adhesion	SNARE Binding Voltage-gated Potassium Channel Activity SNAP Receptor Activity Protein Binding Lipid Binding Syntaxin-1 Binding Calcium-dependent Protein Binding
	Biological Process	SNARE Complex Assembly Regulation Of SNARE Complex Assembly Negative Regulation Of Exocytosis Cell-cell Adhesion	Neurotransmitter Uptake Exocytosis Chemical Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Associative Learning Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization Potassium Ion Transmembrane Transport Presynaptic Dense Core Vesicle Exocytosis
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type C (botC) Toxicity of botulinum toxin type E (botE) Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
Drugs			Botulinum toxin type A Letibotulinumtoxina
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 28892062 28448500 25673413 26961502) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Cataracts ( 34127677) Cognitive decline rate in late mild cognitive impairment ( 26252872) Eosinophil count ( 27863252 32888494) Finger osteoarthritis severity (hand Klsum) ( 33055079) Granulocyte count ( 27863252) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference ( 28552196 25673412) Hippocampal volume ( 21116278) Immature fraction of reticulocytes ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Microalbuminuria in type 1 diabetes ( 31537649) Monocyte count ( 32888494 27863252 29403010) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neuritic plaque ( 31497858) Neutrophil count ( 29403010 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Overweight status ( 25133637) Peanut allergy ( 29030101) Platelet count ( 32888494) Plateletcrit ( 32888494) Protein level change in low calorie diet obesity intervention ( 29234017) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Subcutaneous adipose tissue ( 22589738) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference ( 25673412) White blood cell count ( 29403010 27863252 32888494) White blood cell types ( 21738478) Zinc levels ( 26025379)	Brain imaging measurements (variance) ( 32047264) Cardiac hypertrophy ( 21348951) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603)
Interacting Genes		3 interacting genes: SNAP25 STX1A STX4	45 interacting genes: APP CENPF CPLX1 DNM1 FBXO7 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA OSBP OSBPL10 OSBPL11 OSBPL2 OSBPL5 OSBPL8 PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX19 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 UQCC2 VAMP2 VAMP7 VAMP8 WASHC3 ZDHHC17 ZNF177 ZNF559-ZNF177
Entrez ID		29091	6616
HPRD ID		06410	02637
Ensembl ID		ENSG00000168952	ENSG00000132639
Uniprot IDs		Q8NFX7	P60880
PDB IDs			1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J 6JLH 8BAN 8BAV
Enriched GO Terms of Interacting Partners?		SNARE Complex SNAP Receptor Activity SNARE Binding Vesicle Docking Organelle Localization By Membrane Tethering Membrane Docking Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Neurotransmitter Transport Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Positive Regulation Of Synaptic Transmission Membrane Fusion Regulation Of Insulin Secretion Synaptic Vesicle Docking Regulation Of Peptide Hormone Secretion Exocytosis SNARE Complex Assembly Somatodendritic Compartment Regulation Of Hormone Secretion Regulation Of Protein Secretion Vesicle Organization Neuron Projection Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis Secretion By Cell Vesicle Docking Involved In Exocytosis Regulation Of Protein Transport Organelle Localization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Regulated Secretory Pathway Secretion Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Long-term Synaptic Potentiation Glutamatergic Synapse Regulation Of Secretion By Cell Regulation Of Secretion Membrane Organization Voltage-gated Potassium Channel Complex Calcium-dependent Protein Binding Positive Regulation Of Exocytosis Vesicle-mediated Transport In Synapse Schaffer Collateral - CA1 Synapse Regulated Exocytosis Regulation Of Protein Localization Synapse Regulation Of Regulated Secretory Pathway Myosin Head/neck Binding Sphingomyelin Phosphodiesterase Activator Activity	SNARE Binding Membrane Organization SNARE Complex Membrane Fusion Exocytosis Vesicle Fusion SNAP Receptor Activity Organelle Membrane Fusion Vesicle-mediated Transport Organelle Fusion Regulation Of Exocytosis Organelle Localization By Membrane Tethering Vesicle Organization Secretion By Cell Membrane Docking Vesicle Docking Protein Transport Regulation Of Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Secretion By Cell Establishment Of Localization In Cell Secretion Regulation Of Secretion Intracellular Protein Localization Cellular Localization Intracellular Transport Organelle Localization Synapse Regulation Of Transport Regulation Of Regulated Secretory Pathway Positive Regulation Of Transport Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Positive Regulation Of Exocytosis Intracellular Protein Transport Regulation Of Hormone Secretion Endomembrane System SNARE Complex Assembly Vesicle-mediated Transport In Synapse Cytoplasmic Vesicle Positive Regulation Of Secretion By Cell Synaptic Vesicle Exocytosis Regulated Exocytosis Synaptic Vesicle Membrane Organization Positive Regulation Of Secretion Protein-containing Complex Organization Synaptic Vesicle Membrane Positive Regulation Of Regulated Secretory Pathway Neurotransmitter Transport
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