EML1 and GRID2

Number of citations of the paper that reports this interaction (PMID 11829466)
1

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		EML1	GRID2
Gene Name		echinoderm microtubule associated protein like 1	glutamate receptor, ionotropic, delta 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Microtubule Microtubule Associated Complex Perinuclear Region Of Cytoplasm Mitotic Spindle Pole Mitotic Spindle Midzone	Plasma Membrane Integral Component Of Plasma Membrane Ionotropic Glutamate Receptor Complex Cell Junction Dendrite Dendritic Spine Synapse Postsynaptic Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Microtubule Binding Tubulin Binding	Ionotropic Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Glutamate Receptor Activity PDZ Domain Binding Scaffold Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Hematopoietic Progenitor Cell Differentiation Mitotic Spindle Organization Neuroblast Proliferation Brain Development	Transport Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Glutamate Receptor Signaling Pathway Regulation Of Neuron Projection Development Cerebellar Granule Cell Differentiation Ion Transmembrane Transport Cellular Protein Localization Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Neuron Apoptotic Process Regulation Of Excitatory Postsynaptic Membrane Potential Prepulse Inhibition
Pathways
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: GRID1 GRID2 ISG20L2	10 interactors: AP4M1 DLG2 EML1 GOPC GRIA1 GRID2IP GRIK2 GRIK5 MAGI2 PTPN4
Entrez ID		2009	2895
HPRD ID		03613	06781
Ensembl ID		ENSG00000066629	ENSG00000152208
Uniprot IDs		O00423	E9PH24 O43424
PDB IDs
Enriched GO Terms of Interacting Partners?		Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Cerebellar Granule Cell Differentiation Synaptic Transmission Prepulse Inhibition Cerebellar Granular Layer Morphogenesis Cerebellar Granular Layer Development Cerebellar Cortex Formation Startle Response Cell Differentiation In Hindbrain Cell-cell Signaling Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Social Behavior Cerebellar Cortex Morphogenesis Cerebellum Morphogenesis Hindbrain Morphogenesis Cerebellar Cortex Development Ion Transmembrane Transport Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential	Receptor Clustering Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Neuron-neuron Synaptic Transmission Regulation Of Synaptic Transmission Cellular Protein Localization Protein Retention In ER Lumen Maintenance Of Protein Localization In Endoplasmic Reticulum Protein Localization To Membrane Regulation Of Vesicle-mediated Transport Long Term Synaptic Depression Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Regulation Of Synaptic Plasticity Protein Localization Synaptic Transmission Regulation Of Synaptic Vesicle Exocytosis Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Transport Cellular Localization Positive Regulation Of Neuron Apoptotic Process Membrane Organization Cellular Response To Glucose Stimulus Regulation Of Neurotransmitter Secretion Cell-cell Signaling Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Neuron Death Regulation Of Postsynaptic Membrane Potential Cytoplasmic Sequestering Of CFTR Protein Cellular Glucose Homeostasis Cellular Response To Carbohydrate Stimulus Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Regulation Of Phosphatase Activity Planar Cell Polarity Pathway Involved In Axis Elongation Negative Regulation Of Signaling Membrane Depolarization Protein Localization To Endoplasmic Reticulum Regulation Of Dephosphorylation Response To Glucose Regulation Of Exocytosis Intracellular Transport Cytoplasmic Transport Response To Carbohydrate Negative Regulation Of Golgi To Plasma Membrane Protein Transport Glucose Homeostasis
Tagcloud ?		abnormally apical arisen dcx disability dividing heco heterotopia heterotopic insertion intellectual intron lissencephaly migrated mimicked misplaced mutated neocortex orientations pafah1b1 progenitors reexpression rescued retrotransposon ribbon spindle spontaneously subcortical tuba1a	4q ataxia atrophy biallelic cerebella cerebellar cerebellum deletions evolutionarily exon eye fibers genotyping heterozygous homozygosity homozygous linkage movement movements ortholog purkinje recordings resemblance sanger speech spines synapse tonic upgaze
Tagcloud (Difference) ?		abnormally apical arisen dcx disability dividing heco heterotopia heterotopic insertion intellectual intron lissencephaly migrated mimicked misplaced mutated neocortex orientations pafah1b1 progenitors reexpression rescued retrotransposon ribbon spindle spontaneously subcortical tuba1a	4q ataxia atrophy biallelic cerebella cerebellar cerebellum deletions evolutionarily exon eye fibers genotyping heterozygous homozygosity homozygous linkage movement movements ortholog purkinje recordings resemblance sanger speech spines synapse tonic upgaze
Tagcloud (Intersection) ?