GRIN3B

Description		glutamate ionotropic receptor NMDA type subunit 3B
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane NMDA Selective Glutamate Receptor Complex Monoatomic Ion Channel Complex Presynaptic Membrane Neuronal Cell Body Synapse Postsynaptic Membrane Postsynaptic Density Membrane Neurotransmitter Receptor Complex
	Molecular Function	NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Glycine Binding Neurotransmitter Receptor Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Glycine-gated Cation Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Protein Insertion Into Membrane Regulation Of Calcium Ion Transport Regulation Of Postsynaptic Membrane Potential Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Regulation Of Presynaptic Membrane Potential
Pathways		Assembly and cell surface presentation of NMDA receptors
Drugs		Glycine Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Dextropropoxyphene Acamprosate Donepezil Guaifenesin Memantine Halothane Orphenadrine Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS		Alzheimer's disease (late onset) ( 23571587) Neutrophil count ( 29403010) Red cell distribution width ( 28957414)
Interacting Genes		2 interacting genes: DLG4 GRIN2A
Entrez ID		116444
HPRD ID		09444
Ensembl ID		ENSG00000116032
Uniprot IDs		O60391 Q5F0I5
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Positive Regulation Of Excitatory Postsynaptic Potential Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Glutamate Receptor Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Regulation Of Neuronal Synaptic Plasticity Protein Localization To Synapse Synaptic Membrane Protein Localization To Cell Junction Postsynaptic Density Membrane Neuromuscular Process Regulation Of Nervous System Process Synaptic Vesicle Dendritic Spine Positive Regulation Of Synaptic Transmission Learning P2Y1 Nucleotide Receptor Binding Regulation Of Synaptic Plasticity Protein Localization To Cell Periphery Postsynapse Postsynaptic Membrane Postsynaptic Density Learning Or Memory Cognition Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Chemical Synaptic Transmission Protein Localization To Membrane Directional Locomotion Neuron Projection Trans-synaptic Signaling Synaptic Signaling AMPA Glutamate Receptor Clustering Neuroligin Family Protein Binding Regulation Of Membrane Potential NMDA Selective Glutamate Receptor Signaling Pathway D1 Dopamine Receptor Binding Modulation Of Chemical Synaptic Transmission NMDA Glutamate Receptor Activity Sleep Cerebellar Mossy Fiber Synaptic Vesicle Maturation Neuron Spine Positive Regulation Of Neuron Projection Arborization Localization Within Membrane Glutamatergic Synapse Regulation Of System Process NMDA Selective Glutamate Receptor Complex
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