OSTM1 and RGS19

Number of citations of the paper that reports this interaction (PMID 12826607)
10

Data Source:
HPRD (two hybrid, in vitro)

		OSTM1	RGS19
Gene Name		osteopetrosis associated transmembrane protein 1	regulator of G-protein signaling 19
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lysosomal Membrane Cytosol Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane Brush Border Membrane Clathrin-coated Vesicle
	Molecular Function		G-protein Alpha-subunit Binding GTPase Activator Activity Protein Binding
	Biological Process	Osteoclast Differentiation Ion Transmembrane Transport Transmembrane Transport	Autophagy G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		Ion channel transport Stimuli-sensing channels	G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK G alpha (z) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CLCN7 GPSM1 LIG4 RGS17 RGS19 RGS20	15 interactors: CSNK2A1 CSNK2A2 GDE1 GIPC1 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ MAPK1 MAPK6 OPRL1 OSTM1 PRKCA TGFBR1
Entrez ID		28962	10287
HPRD ID		09628	05461
Ensembl ID		ENSG00000081087	ENSG00000171700
Uniprot IDs		Q86WC4	B4DP94 P49795
PDB IDs			1CMZ
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway DNA Ligation Involved In DNA Recombination Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Regulation Of Catalytic Activity Lagging Strand Elongation Pro-B Cell Differentiation Positive Regulation Of Hydrolase Activity Negative Regulation Of Signal Transduction Establishment Of Integrated Proviral Latency Negative Regulation Of Signaling Establishment Of Viral Latency Immunoglobulin V(D)J Recombination Regulation Of Signal Transduction DNA Ligation Involved In DNA Repair T Cell Receptor V(D)J Recombination Lymphoid Progenitor Cell Differentiation Regulation Of Signaling DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Cellular Response To Lithium Ion Positive Regulation Of Catalytic Activity Single Strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Isotype Switching V(D)J Recombination DNA Strand Elongation Involved In DNA Replication Response To Lithium Ion DNA Strand Elongation Response To X-ray Somatic Recombination Of Immunoglobulin Gene Segments Response To PH Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response Response To Gamma Radiation Neuron Apoptotic Process	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Cell Cycle Synaptic Transmission Platelet Activation G-protein Coupled Receptor Signaling Pathway Signal Transduction Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Signaling Cell-cell Signaling Cell Communication Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Wound Healing Negative Regulation Of Nucleotide Metabolic Process Cell Activation Response To Wounding Peptidyl-threonine Phosphorylation Cellular Response To Stimulus Blood Coagulation Hemostasis Regulation Of Adenylate Cyclase Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Activation Of MAPKK Activity Regulation Of Cyclase Activity Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Body Fluid Levels Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Response To Stimulus Negative Regulation Of Protein Catabolic Process Peptidyl-serine Phosphorylation Locomotion Positive Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Proliferation Positive Regulation Of MAPK Cascade Movement Of Cell Or Subcellular Component Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Proteasomal Protein Catabolic Process Apoptotic Process Programmed Cell Death Mitotic Spindle Checkpoint
Tagcloud ?		anhydrase arthritis carbonic cathepsin chalcone clcn7 destructive elucidate expressions fos gab2 modulating multinucleated nfatc1 osteoclast osteoclastogenesis osteoclasts osteoporosis periodontitis pit prenylated rankl raw264 resorption structurally suppress tcirg traf6 xanthohumol	accelerating adenylate c6 cyclase dampen depressant galphai galphai2 gap gaps go gpcr gpcrs gtpase hairpin ht1a implicating insensitive medications mood neuroblastoma postsynaptic prefrontal raphe shrna sy5y synergy viable
Tagcloud (Difference) ?		anhydrase arthritis carbonic cathepsin chalcone clcn7 destructive elucidate expressions fos gab2 modulating multinucleated nfatc1 osteoclast osteoclastogenesis osteoclasts osteoporosis periodontitis pit prenylated rankl raw264 resorption structurally suppress tcirg traf6 xanthohumol	accelerating adenylate c6 cyclase dampen depressant galphai galphai2 gap gaps go gpcr gpcrs gtpase hairpin ht1a implicating insensitive medications mood neuroblastoma postsynaptic prefrontal raphe shrna sy5y synergy viable
Tagcloud (Intersection) ?