LAMTOR2 and LAMTOR3

Number of citations of the paper that reports this interaction (PubMedID 11266467)
52

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		LAMTOR2	LAMTOR3
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 2	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Plasma Membrane Endosome Membrane Membrane Late Endosome Membrane Specific Granule Membrane Tertiary Granule Membrane Ragulator Complex FNIP-folliculin RagC/D GAP	Cytoplasm Lysosomal Membrane Endosome Late Endosome Plasma Membrane Focal Adhesion Endosome Membrane Membrane Late Endosome Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Ragulator Complex FNIP-folliculin RagC/D GAP
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Activator Activity Molecular Adaptor Activity
	Biological Process	Regulation Of Cell Growth Intracellular Protein Localization Fibroblast Migration Positive Regulation Of TOR Signaling TORC1 Signaling Positive Regulation Of MAPK Cascade Cellular Response To Amino Acid Stimulus Regulation Of Cell-substrate Junction Organization Protein Localization To Cell Junction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of TORC1 Signaling	Intracellular Protein Localization Regulation Of TOR Signaling Positive Regulation Of TOR Signaling TORC1 Signaling Positive Regulation Of MAPK Cascade Cellular Response To Amino Acid Stimulus Protein Localization To Cell Junction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of TORC1 Signaling
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes MAP2K and MAPK activation Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes MAP2K and MAPK activation Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS			Mean reticulocyte volume ( 32888494)
Interacting Genes		2 interacting genes: ERBB3 LAMTOR3	20 interacting genes: ADAMTS10 APOL6 BHMT CEBPZ CPNE6 IBTK LAMTOR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MBD2 NIF3L1 PDE4DIP QARS1 SUFU TFE3 TGM7 UBR1 ZSCAN4
Entrez ID		28956	8649
HPRD ID		17463	04485
Ensembl ID		ENSG00000116586	ENSG00000109270
Uniprot IDs		Q9Y2Q5	Q9UHA4
PDB IDs		5X6U 5X6V 5Y39 5Y3A 5YK3 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB	1SKO 2ZL1 3CPT 5X6U 5X6V 5Y39 5Y3A 5YK3 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cardiac Muscle Tissue Development ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Neuregulin Receptor Activity Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Ragulator Complex ERBB2-ERBB3 Signaling Pathway Positive Regulation Of MAPK Cascade Schwann Cell Differentiation ERBB3 Signaling Pathway FNIP-folliculin RagC/D GAP Negative Regulation Of Motor Neuron Apoptotic Process Regulation Of MAPK Cascade Endocardial Cushion Development Kinase Activator Activity Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Protein Tyrosine Kinase Activator Activity Schwann Cell Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Striated Muscle Tissue Development ERBB2 Signaling Pathway Peripheral Nervous System Development Cranial Nerve Development Positive Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Striated Muscle Tissue Development Growth Factor Binding Regulation Of Muscle Organ Development Nerve Development Positive Regulation Of Calcium-mediated Signaling Basal Plasma Membrane Mesenchyme Development Glial Cell Development Lateral Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway TORC1 Signaling Tertiary Granule Membrane Positive Regulation Of TORC1 Signaling Positive Regulation Of Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Communication ERBB Signaling Pathway Wound Healing Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Calcium-mediated Signaling	Regulation Of Golgi Inheritance Regulation Of Golgi Organization Trachea Formation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Stress-activated MAPK Cascade Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Animal Organ Formation Face Development ERBB2 Signaling Pathway Lung Morphogenesis Thyroid Gland Development Insulin-like Growth Factor Receptor Signaling Pathway Bergmann Glial Cell Differentiation Thymus Development ERK1 And ERK2 Cascade Late Endosome Glial Cell Development ERBB Signaling Pathway Myelination Interleukin-34-mediated Signaling Pathway Axon Ensheathment Hematopoietic Or Lymphoid Organ Development Astrocyte Differentiation Regulation Of Intracellular Transport Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Epithelial Cell Proliferation Involved In Lung Morphogenesis Cardiac Neural Crest Cell Development Involved In Heart Development Outer Ear Morphogenesis Molecular Adaptor Activity Regulation Of MAPK Cascade MAP-kinase Scaffold Activity MAPK Cascade MAP Kinase Kinase Activity MAP Kinase Activity Pseudopodium Regulation Of DNA-templated Transcription Gland Development Regulation Of RNA Biosynthetic Process Positive Regulation Of Macrophage Chemotaxis Glial Cell Differentiation Positive Regulation Of Neuroinflammatory Response Regulation Of Cellular Localization Regulation Of Cellular Response To Stress Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Cytoplasm
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