LAMTOR2

Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Plasma Membrane Endosome Membrane Membrane Late Endosome Membrane Specific Granule Membrane Tertiary Granule Membrane Ragulator Complex FNIP-folliculin RagC/D GAP
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity
	Biological Process	Regulation Of Cell Growth Intracellular Protein Localization Fibroblast Migration Positive Regulation Of TOR Signaling TORC1 Signaling Positive Regulation Of MAPK Cascade Cellular Response To Amino Acid Stimulus Regulation Of Cell-substrate Junction Organization Protein Localization To Cell Junction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of TORC1 Signaling
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes MAP2K and MAPK activation Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS
Interacting Genes		2 interacting genes: ERBB3 LAMTOR3
Entrez ID		28956
HPRD ID		17463
Ensembl ID		ENSG00000116586
Uniprot IDs		Q9Y2Q5
PDB IDs		5X6U 5X6V 5Y39 5Y3A 5YK3 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cardiac Muscle Tissue Development ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Neuregulin Receptor Activity Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Ragulator Complex ERBB2-ERBB3 Signaling Pathway Positive Regulation Of MAPK Cascade Schwann Cell Differentiation ERBB3 Signaling Pathway FNIP-folliculin RagC/D GAP Negative Regulation Of Motor Neuron Apoptotic Process Regulation Of MAPK Cascade Endocardial Cushion Development Kinase Activator Activity Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Protein Tyrosine Kinase Activator Activity Schwann Cell Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Striated Muscle Tissue Development ERBB2 Signaling Pathway Peripheral Nervous System Development Cranial Nerve Development Positive Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Striated Muscle Tissue Development Growth Factor Binding Regulation Of Muscle Organ Development Nerve Development Positive Regulation Of Calcium-mediated Signaling Basal Plasma Membrane Mesenchyme Development Glial Cell Development Lateral Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway TORC1 Signaling Tertiary Granule Membrane Positive Regulation Of TORC1 Signaling Positive Regulation Of Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Communication ERBB Signaling Pathway Wound Healing Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Calcium-mediated Signaling
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