GRIA2 and CLCN3

		GRIA2	CLCN3
Description		glutamate ionotropic receptor AMPA type subunit 2	chloride voltage-gated channel 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Postsynaptic Density Membrane Dendrite Endocytic Vesicle Membrane Asymmetric Synapse AMPA Glutamate Receptor Complex Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Postsynapse Postsynaptic Density Membrane Postsynaptic Endocytic Zone	Golgi Membrane Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Endosome Membrane Vesicle Membrane Membrane Secretory Granule Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Ruffle Membrane Specific Granule Cell Projection Axon Terminus Phagocytic Vesicle Recycling Endosome Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Amyloid-beta Binding Glutamate-gated Receptor Activity AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Cation Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Nucleotide Binding Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity PDZ Domain Binding Chloride:proton Antiporter Activity Volume-sensitive Chloride Channel Activity
	Biological Process	Monoatomic Ion Transport Signal Transduction Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Monoatomic Cation Transmembrane Transport	Monoatomic Ion Transport Chloride Transport Regulation Of PH Phagocytosis, Engulfment Adult Locomotory Behavior Synaptic Transmission, Glutamatergic Photoreceptor Cell Maintenance Negative Regulation Of Cell Volume Endosomal Lumen Acidification Synaptic Transmission, GABAergic Transmembrane Transport Neuron Cellular Homeostasis Synaptic Vesicle Lumen Acidification Chloride Transmembrane Transport Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways		Activation of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation MECP2 regulates neuronal receptors and channels Long-term potentiation	Stimuli-sensing channels
Drugs		Glutamic acid Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Ethanol Phenobarbital Quinidine barbiturate Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione (S)-DES-ME-AMPA (S)-AMPA 2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic Acid Iodo-Willardiine Fluoro-Willardiine Quisqualic acid (S)-2-Amino-3-(1,3,5,7-Pentahydro-2,4-Dioxo-Cyclopenta[E]Pyrimidin-1-Yl) Proionic Acid (2S)-2-Ammonio-3-[5-(2-methyl-2-propanyl)-3-oxido-1,2-oxazol-4-yl]propanoate FG-9041 Bromo-Willardiine Willardiine 2-Amino-3-(3-Hydroxy-7,8-Dihydro-6h-Cyclohepta[D]-4-Isoxazolyl)Propionic Acid Aniracetam THIO-ATPA Talampanel CX-717 N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dimethanesulfonamide 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide Fluciclovine (18F)
Diseases
GWAS		Triglyceride levels x loop diuretics use interaction ( 31806883)	Autism spectrum disorder or schizophrenia ( 28540026) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 25056061 28991256 29483656 30285260)
Interacting Genes		21 interacting genes: CTTN CYLD DRD2 FXR1 GAPDH GRIA3 GRIP2 GSK3B GTF3C2 ITGB3 NSF PICK1 PRKCA RAC1 RNF167 SDCBP SPTAN1 SPTBN1 SQSTM1 SYT3 TSPAN7	6 interacting genes: CFTR DNAJC5 GOPC HSPB1 NHERF1 PDZK1
Entrez ID		2891	1182
HPRD ID		04726	02785
Ensembl ID		ENSG00000120251	ENSG00000109572
Uniprot IDs		A0A994J4F1 P42262	B3KXK0 E9PE15 P51790
PDB IDs		2WJW 2WJX 2XHD 3R7X 3RN8 3RNN 3UA8 5H8S 5YBF 5YBG 5ZG0 5ZG1 5ZG2 5ZG3 7F3O 8I0B
Enriched GO Terms of Interacting Partners?		Glutamatergic Synapse Plasma Membrane Regulation Of Synaptic Plasticity Regulation Of Biological Quality Positive Regulation Of Signaling Regulation Of Organelle Organization Synapse Modulation Of Chemical Synaptic Transmission Regulation Of Signaling Regulation Of Cytoskeleton Organization Regulation Of Vesicle-mediated Transport Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Cell Communication Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Cellular Component Organization Chemical Synaptic Transmission Regulation Of Receptor Internalization Localization Within Membrane Trans-synaptic Signaling Regulation Of Actin Cytoskeleton Organization Synaptic Signaling Regulation Of Secretion By Cell Alphav-beta3 Integrin-PKCalpha Complex Vesicle-mediated Transport Regulation Of Actin Filament-based Process Ionotropic Glutamate Receptor Binding Regulation Of Secretion Cellular Component Assembly Postsynapse Membrane Membrane Organization Positive Regulation Of Signal Transduction Regulation Of Cellular Component Size Positive Regulation Of Protein Localization Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Actin Filament Polymerization Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Actin Filament Organization Positive Regulation Of Developmental Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Neuron Projection Organization Regulation Of Actin Polymerization Or Depolymerization Protein Kinase C Binding Regulation Of Actin Filament Length Intracellular Membraneless Organelle	Regulation Of Monoatomic Anion Transport PDZ Domain Binding Chloride Channel Regulator Activity Regulation Of Monoatomic Ion Transport Golgi-associated Vesicle Membrane 14-3-3 Protein Binding Apical Plasma Membrane Regulation Of Transport Lysosomal Membrane Microvillus Membrane Protein-membrane Adaptor Activity Vesicle Docking Involved In Exocytosis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of Protein Kinase C Signaling Metanephric Glomerular Mesangial Cell Development Renal Phosphate Ion Absorption Negative Regulation Of Anion Channel Activity
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