TRIM59 and PPM1L

		TRIM59	PPM1L
Description		tripartite motif containing 59	protein phosphatase, Mg2+/Mn2+ dependent 1L
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intraciliary Transport Particle B	Endoplasmic Reticulum Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Hydrolase Activity Cation Binding Metal Ion Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Host-mediated Suppression Of Symbiont Invasion	MAPK Cascade Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sphingolipid Biosynthetic Process
Pathways			Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Bipolar disorder ( 31043756) Eosinophil percentage of white cells ( 32888494) Intrinsic epigenetic age acceleration ( 29374233) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)	Kawasaki disease ( 22446961) Malaria ( 31844061) Metabolite levels ( 23823483) Morning person ( 30696823) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Response to methotrexate in rheumatoid arthritis ( 24583629)
Interacting Genes		29 interacting genes: ANKRD33 BLZF1 CCDC33 CDK5 CLDN4 ECSIT EIF2B1 ESR1 ESR2 KEAP1 KRTAP13-3 MACROH2A1 MEI4 MRPL12 NECAB2 NRM PIN1 PKNOX1 PLLP RASSF3 RHOU SEC22A SNAP47 SYVN1 UBE2J2 UBE2W VTI1B ZDHHC21 ZDHHC22	3 interacting genes: EPHA2 MAP3K7 PDGFRB
Entrez ID		286827	151742
HPRD ID		15568	17889
Ensembl ID		ENSG00000213186	ENSG00000163590
Uniprot IDs		Q8IWR1	Q5SGD2
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Estrogen Receptor Activity SNAP Receptor Activity Negative Regulation Of Response To Oxidative Stress	Positive Regulation Of Catalytic Activity Response To Growth Factor Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Locomotion Blood Vessel Morphogenesis Notochord Cell Development Positive Regulation Of Cell Migration Transmembrane Receptor Protein Tyrosine Kinase Activity Kinase Activity Protein Kinase Activity Regulation Of Catalytic Activity Positive Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Transferase Activity Cell Migration Involved In Coronary Angiogenesis Regulation Of Smooth Muscle Cell Migration Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of MAP Kinase Activity Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Axial Mesoderm Formation Regulation Of Smooth Muscle Cell Proliferation Smooth Muscle Cell Chemotaxis Glomerular Mesangial Cell Proliferation Platelet-derived Growth Factor Beta-receptor Activity Platelet-derived Growth Factor Receptor Activity Negative Regulation Of Lymphangiogenesis Regulation Of Cell Migration Notochord Formation Positive Regulation Of Metanephric Mesenchymal Cell Migration Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Metanephric Glomerular Capillary Formation Platelet Activating Factor Receptor Activity I-kappaB Phosphorylation Linear Polyubiquitin Binding Receptor Complex Regulation Of Cell Motility Cell Chemotaxis Regulation Of Locomotion Cell Migration Involved In Vasculogenesis
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