TM4SF4 and GPR101

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TM4SF4	GPR101
Description		transmembrane 4 L six family member 4	G protein-coupled receptor 101
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Plasma Membrane Membrane Receptor Complex
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Tissue Regeneration	Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33339817 33547301) Alanine transaminase levels ( 29403010) Gallstone disease ( 27094239 30504769) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Serum alkaline phosphatase levels ( 33547301) Serum uric acid levels ( 30993211) Thyroid stimulating hormone levels ( 30367059 32769997) Urate levels ( 31578528)	Body mass index ( 28892062)
Interacting Genes		22 interacting genes: APH1B CD79A CLEC17A CMTM2 CREB3 ERGIC3 FATE1 FFAR2 GJB1 GJB4 GJB5 GLP1R GPR101 GPR37L1 GPR42 GPX8 KCNK5 LHFPL5 OPRM1 SLC10A6 TBXA2R TMEM14B	20 interacting genes: AGPAT4 C1GALT1 CDIPT CYB561A3 DERL3 LAT NDUFB11 ORMDL3 RTP2 SLC35E4 SLC39A9 SLC41A1 SLC61A1 THSD7B TM4SF4 TMEM147 TMEM239 UNC93A UNC93B1 YIPF6
Entrez ID		7104	83550
HPRD ID		07585	02315
Ensembl ID		ENSG00000169903	ENSG00000165370
Uniprot IDs		P48230	Q96P66
PDB IDs			8W8Q 8W8R 8W8S
Enriched GO Terms of Interacting Partners?		Membrane G Protein-coupled Receptor Activity Connexin Complex Gap Junction Channel Activity Gap Junction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Peptide Receptor Activity G Protein-coupled Receptor Signaling Pathway Plasma Membrane Transmembrane Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Glucagon-like Peptide 1 Receptor Activity Positive Regulation Of Blood Pressure Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Positive Regulation Of Deacetylase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Negative Regulation Of Blood Pressure	Membrane CDP-diacylglycerol Metabolic Process Intestinal Epithelial Cell Development Columnar/cuboidal Epithelial Cell Development
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