TM4SF4 and GJB4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TM4SF4	GJB4
Description		transmembrane 4 L six family member 4	gap junction protein beta 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Nucleoplasm Nucleolus Plasma Membrane Gap Junction Connexin Complex Membrane Cell Junction Anchoring Junction
	Molecular Function	Protein Binding	Gap Junction Channel Activity Protein Binding
	Biological Process	Tissue Regeneration	Cell Communication Cell-cell Signaling Sensory Perception Of Smell Olfactory Behavior Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways			Gap junction assembly
Drugs
Diseases			Erythrokeratodermia variabilis
GWAS		Alanine aminotransferase levels ( 33339817 33547301) Alanine transaminase levels ( 29403010) Gallstone disease ( 27094239 30504769) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Serum alkaline phosphatase levels ( 33547301) Serum uric acid levels ( 30993211) Thyroid stimulating hormone levels ( 30367059 32769997) Urate levels ( 31578528)	Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		22 interacting genes: APH1B CD79A CLEC17A CMTM2 CREB3 ERGIC3 FATE1 FFAR2 GJB1 GJB4 GJB5 GLP1R GPR101 GPR37L1 GPR42 GPX8 KCNK5 LHFPL5 OPRM1 SLC10A6 TBXA2R TMEM14B	9 interacting genes: ARLN COMT KLRC1 LHFPL5 TM4SF4 TMBIM6 TMEM11 TMEM218 TMEM86A
Entrez ID		7104	127534
HPRD ID		07585	05666
Ensembl ID		ENSG00000169903	ENSG00000189433
Uniprot IDs		P48230	Q9NTQ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane G Protein-coupled Receptor Activity Connexin Complex Gap Junction Channel Activity Gap Junction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Peptide Receptor Activity G Protein-coupled Receptor Signaling Pathway Plasma Membrane Transmembrane Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Glucagon-like Peptide 1 Receptor Activity Positive Regulation Of Blood Pressure Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Positive Regulation Of Deacetylase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Negative Regulation Of Blood Pressure
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