DPH3 and SERGEF

Number of citations of the paper that reports this interaction (PMID 14980502)
3

Data Source:
HPRD (in vivo, two hybrid)

		DPH3	SERGEF
Gene Name		diphthamide biosynthesis 3	secretion regulating guanine nucleotide exchange factor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleolus Cytoplasm Intermediate Filament Cytoskeleton
	Molecular Function	Protein Binding Metal Ion Binding	Ran Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Peptidyl-diphthamide Biosynthetic Process From Peptidyl-histidine Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Protein Secretion Positive Regulation Of Binding	Signal Transduction Positive Regulation Of Ran GTPase Activity Negative Regulation Of Protein Secretion
Pathways		Synthesis of diphthamide-EEF2 Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ADIPOR1 PIH1D2 RPL8 SERGEF	4 interactors: DPH3 EXOC2 KDM1A PRMT6
Entrez ID		285381	26297
HPRD ID		16412	06926
Ensembl ID			ENSG00000129158
Uniprot IDs		Q96FX2	A8K8C1 Q9UGK8
PDB IDs		2JR7
Enriched GO Terms of Interacting Partners?		Leptin-mediated Signaling Pathway Adiponectin-activated Signaling Pathway Positive Regulation Of Ran GTPase Activity Cellular Response To Leptin Stimulus Response To Leptin	Regulation Of Primitive Erythrocyte Differentiation Histone H3-R2 Methylation Regulation Of Binding Cellular Protein Metabolic Process Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Histone Modification Positive Regulation Of Megakaryocyte Differentiation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Positive Regulation Of Hormone Biosynthetic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H4-R3 Methylation Peptidyl-diphthamide Biosynthetic Process From Peptidyl-histidine Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Granulocyte Differentiation Peptidyl-arginine N-methylation Protein Metabolic Process Regulation Of Megakaryocyte Differentiation Negative Regulation Of Histone Methylation Positive Regulation Of Erythrocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Histone Arginine Methylation Chromatin Modification Peptidyl-arginine Methylation Regulation Of Histone H3-K4 Methylation Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Hormone Biosynthetic Process Chromatin Organization Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Lysine Demethylation Regulation Of Hormone Metabolic Process Golgi To Plasma Membrane Transport Histone Demethylation Regulation Of Erythrocyte Differentiation Protein Demethylation Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of DNA Binding Organelle Organization Cellular Protein Modification Process Peptidyl-amino Acid Modification Regulation Of Histone Methylation Positive Regulation Of Neural Precursor Cell Proliferation Pituitary Gland Development Negative Regulation Of Protein Binding Chromosome Organization
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