SERGEF

Description		secretion regulating guanine nucleotide exchange factor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Signal Transduction Negative Regulation Of Protein Secretion
Pathways
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Bipolar disorder ( 34099189) Body mass index ( 26426971)
Interacting Genes		9 interacting genes: DPH3 EXOC2 FOXH1 HGS KDM1A LCOR PITX1 PRMT6 SPAG8
Entrez ID		26297
HPRD ID		06926
Ensembl ID		ENSG00000129158
Uniprot IDs		A8K8C1 Q9UGK8
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Androgen Receptor Binding Transcription Corepressor Activity Regulation Of Androgen Receptor Signaling Pathway Membrane Fission Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Histone H2AR3 Methyltransferase Activity Branchiomeric Skeletal Muscle Development Myoblast Fate Commitment Activin Responsive Factor Complex Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Embryonic Heart Tube Anterior/posterior Pattern Specification Negative Regulation Of Transcription By RNA Polymerase II ESCRT-0 Complex Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone H3R2 Methyltransferase Activity Histone Arginine N-methyltransferase Activity TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Iron Chaperone Activity Regulation Of Signal Transduction By P53 Class Mediator Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Phagocytic Vesicle Lumen Vesicle-mediated Transport To The Plasma Membrane Protein Demethylase Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Axial Mesoderm Development Response To Fungicide MRF Binding Guanine Metabolic Process Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Regulation Of Entry Of Bacterium Into Host Cell Protein Histidyl Modification To Diphthamide DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone H3K4 Demethylase Activity
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