SERGEF and DPH3

Number of citations of the paper that reports this interaction (PMID 14980502)
3

Data Source:
HPRD (in vivo, two hybrid)

		SERGEF	DPH3
Gene Name		secretion regulating guanine nucleotide exchange factor	diphthamide biosynthesis 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Ran Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Metal Ion Binding
	Biological Process	Signal Transduction Positive Regulation Of Ran GTPase Activity Negative Regulation Of Protein Secretion	Peptidyl-diphthamide Biosynthetic Process From Peptidyl-histidine Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Protein Secretion Positive Regulation Of Binding
Pathways			Synthesis of diphthamide-EEF2 Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: DPH3 EXOC2 KDM1A PRMT6	4 interactors: ADIPOR1 PIH1D2 RPL8 SERGEF
Entrez ID		26297	285381
HPRD ID		06926	16412
Ensembl ID		ENSG00000129158
Uniprot IDs		A8K8C1 Q9UGK8	Q96FX2
PDB IDs			2JR7
Enriched GO Terms of Interacting Partners?		Regulation Of Primitive Erythrocyte Differentiation Histone H3-R2 Methylation Regulation Of Binding Cellular Protein Metabolic Process Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Histone Modification Positive Regulation Of Megakaryocyte Differentiation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Positive Regulation Of Hormone Biosynthetic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H4-R3 Methylation Peptidyl-diphthamide Biosynthetic Process From Peptidyl-histidine Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Granulocyte Differentiation Peptidyl-arginine N-methylation Protein Metabolic Process Regulation Of Megakaryocyte Differentiation Negative Regulation Of Histone Methylation Positive Regulation Of Erythrocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Histone Arginine Methylation Chromatin Modification Peptidyl-arginine Methylation Regulation Of Histone H3-K4 Methylation Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Hormone Biosynthetic Process Chromatin Organization Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Lysine Demethylation Regulation Of Hormone Metabolic Process Golgi To Plasma Membrane Transport Histone Demethylation Regulation Of Erythrocyte Differentiation Protein Demethylation Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of DNA Binding Organelle Organization Cellular Protein Modification Process Peptidyl-amino Acid Modification Regulation Of Histone Methylation Positive Regulation Of Neural Precursor Cell Proliferation Pituitary Gland Development Negative Regulation Of Protein Binding Chromosome Organization	Leptin-mediated Signaling Pathway Adiponectin-activated Signaling Pathway Positive Regulation Of Ran GTPase Activity Cellular Response To Leptin Stimulus Response To Leptin
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