GPR22 and TFAP2C

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		GPR22	TFAP2C
Name		G protein-coupled receptor 22	transcription factor AP-2 gamma
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Chromatin Nucleus Nucleoplasm Mitochondrion Cytosol
	Molecular Function	G Protein-coupled Receptor Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell Projection Organization Cellular Response To Hormone Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Inner Cell Mass Cell Differentiation Trophectodermal Cell Differentiation Hair Follicle Development Keratinocyte Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell-cell Signaling Male Gonad Development Stem Cell Population Maintenance Forebrain Neuron Fate Commitment Cerebral Cortex Development Germ-line Stem Cell Population Maintenance Epithelial Cell Differentiation Somatic Stem Cell Population Maintenance Regulation Of Cell Population Proliferation Skin Development Regulation Of Epidermis Development Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription By RNA Polymerase II Sebaceous Gland Development Stem Cell Differentiation Dichotomous Subdivision Of Terminal Units Involved In Mammary Gland Duct Morphogenesis Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Morula Formation
Pathways		None	SUMOylation of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors TFAP2 (AP-2) family regulates transcription of cell cycle factors Specification of primordial germ cells Specification of the neural plate border Specification of the neural plate border Developmental Lineage of Mammary Stem Cells
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Blond vs. brown/black hair color ( 30531825 ) Blood urea nitrogen levels ( 31152163 ) Cerebrospinal P-tau181p levels ( 28247064 ) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Maximum stenosis ( 32469969 ) Mean degree of stenosis ( 32469969 ) Ovarian cancer ( 30557369 ) Refractive error ( 32231278 ) Sum of stenosis ( 32469969 )
Novel Interactors		None recorded	1 novel interactors: BLK
Interacting Genes		3 interacting genes: CEBPE NFATC4 TFAP2C	12 interacting genes: CCNG1 CITED1 CITED2 CITED4 ERBB4 GPR22 IKBKB NR1I2 TP53 UBE2I WWOX ZFAND4
Entrez ID		2845	7022
HPRD ID		03552	03361
Ensembl ID		ENSG00000172209	ENSG00000087510
Uniprot IDs		B3KV13 Q3KNS9 Q99680	Q92754
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		DNA-templated Transcription Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nucleobase-containing Compound Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Dichotomous Subdivision Of Terminal Units Involved In Mammary Gland Duct Morphogenesis RNA Metabolic Process Negative Regulation Of Synapse Maturation Morula Formation Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Brain-derived Neurotrophic Factor Receptor Signaling Pathway Transcription By RNA Polymerase II DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Germ-line Stem Cell Population Maintenance Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Morphogenesis Of An Epithelium Inner Cell Mass Cell Differentiation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Dendrite Morphogenesis Vascular Associated Smooth Muscle Cell Differentiation Sebaceous Gland Development Forebrain Neuron Fate Commitment Tissue Morphogenesis DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Keratinocyte Development Vascular Associated Smooth Muscle Cell Development Cell Differentiation Negative Regulation Of Synapse Organization Cellular Response To Lithium Ion Synapse Maturation Mammary Gland Epithelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Response To Lithium Ion Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Trophectodermal Cell Differentiation Calcineurin-NFAT Signaling Cascade Positive Regulation Of Biosynthetic Process Cellular Developmental Process Smooth Muscle Cell Differentiation Negative Regulation Of MiRNA Transcription Regulation Of Synapse Maturation	Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process LBD Domain Binding Response To Estrogen Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of DNA-templated Transcription Positive Regulation Of Signal Transduction Response To Growth Factor Regulation Of RNA Biosynthetic Process Transcription Coactivator Activity Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Molecular Function Activator Activity Positive Regulation Of Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Primary Metabolic Process Cell Differentiation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Establishment Of Planar Polarity Involved In Nephron Morphogenesis Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition SUMO Conjugating Enzyme Activity Nuclear Transport Nucleocytoplasmic Transport Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Signal Transduction Response To Hormone Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Heart Development Regulation Of Macromolecule Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Intracellular Signal Transduction Apoptotic Mitochondrial Changes Vasculogenesis Cellular Senescence Intracellular Signal Transduction Regulation Of Cell Communication