GPR22 and TFAP2C

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GPR22	TFAP2C
Gene Name		G protein-coupled receptor 22	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane	Nucleus
	Molecular Function	G-protein Coupled Receptor Activity Peptide Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Dimerization Activity
	Biological Process	G-protein Coupled Receptor Signaling Pathway Cellular Response To Hormone Stimulus Response To Peptide	Negative Regulation Of Transcription From RNA Polymerase II Promoter Trophectodermal Cell Differentiation Hair Follicle Development Keratinocyte Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell-cell Signaling Male Gonad Development Forebrain Neuron Fate Commitment Cerebral Cortex Development Germ-line Stem Cell Maintenance Somatic Stem Cell Maintenance Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Regulation Of Epidermis Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Sebaceous Gland Development Dichotomous Subdivision Of Terminal Units Involved In Mammary Gland Duct Morphogenesis Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CEBPE NFATC4 TFAP2C	10 interactors: CCNG1 CITED1 CITED2 CITED4 GPR22 IKBKB NR1I2 TP53 UBE2I ZFAND4
Entrez ID		2845	7022
HPRD ID		03552	03361
Ensembl ID		ENSG00000172209	ENSG00000087510
Uniprot IDs		A4D0R8 B3KV13 Q3KNS9 Q99680	Q92754
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Branching Morphogenesis Of An Epithelial Tube Dichotomous Subdivision Of Terminal Units Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Morphogenesis Of A Branching Epithelium Positive Regulation Of Cellular Biosynthetic Process Morphogenesis Of A Branching Structure Regulation Of Transcription From RNA Polymerase II Promoter Epithelial Tube Morphogenesis Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Germ-line Stem Cell Maintenance Branch Elongation Involved In Mammary Gland Duct Branching Transcription, DNA-templated Tube Morphogenesis RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Keratinocyte Development Morphogenesis Of An Epithelium Sebaceous Gland Development Cellular Response To Lithium Ion Organ Development Tissue Morphogenesis Forebrain Neuron Fate Commitment Macrophage Differentiation RNA Metabolic Process Tube Development Mammary Gland Epithelial Cell Proliferation Cytokine Biosynthetic Process Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Trophectodermal Cell Differentiation Branch Elongation Of An Epithelium Cellular Macromolecule Biosynthetic Process Response To Lithium Ion Cytokine Metabolic Process Macromolecule Biosynthetic Process Axis Elongation Blastocyst Formation System Development Anatomical Structure Formation Involved In Morphogenesis Patterning Of Blood Vessels Regulation Of Transcription, DNA-templated Epithelium Development Negative Regulation Of Transcription, DNA-templated Branching Involved In Mammary Gland Duct Morphogenesis	Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Hormone Negative Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Signal Transduction Negative Regulation Of Gene Expression Response To Estrogen Negative Regulation Of Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Regulation Of Transcription, DNA-templated Response To Lipid Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Response To Organic Cyclic Compound Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Drug Export Response To Interleukin-11 Positive Regulation Of SUMO Transferase Activity Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Pattern Specification Process Cellular Response To Hypoxia Regulation Of Metabolic Process Cellular Response To Decreased Oxygen Levels Embryonic Organ Development Transcription, DNA-templated Negative Regulation Of Macromitophagy
Tagcloud ?		asymmetry cilia ciliogenesis details foxj1a gpcr gpcrs knock kupffer kv lefty1 lefty2 looping lpm lr master mesodermal morpholino organelles orphan patterning pitx2a player protrude randomization rfx2 southpaw tem vesicle	achieved additionally basal biopsy breast cd44 chemotherapy cluster cores immunohistochemistry luminal mb mda neoadjuvant overexpression pathologic pcr plasmid predictive pretreatment receiving regulates repressed represses residual specimens stained tumors
Tagcloud (Difference) ?		asymmetry cilia ciliogenesis details foxj1a gpcr gpcrs knock kupffer kv lefty1 lefty2 looping lpm lr master mesodermal morpholino organelles orphan patterning pitx2a player protrude randomization rfx2 southpaw tem vesicle	achieved additionally basal biopsy breast cd44 chemotherapy cluster cores immunohistochemistry luminal mb mda neoadjuvant overexpression pathologic pcr plasmid predictive pretreatment receiving regulates repressed represses residual specimens stained tumors
Tagcloud (Intersection) ?