GPR22 and NFATC4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GPR22	NFATC4
Gene Name		G protein-coupled receptor 22	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane	Nucleus Transcription Factor Complex Cytoplasm Cytosol Intermediate Filament Cytoskeleton
	Molecular Function	G-protein Coupled Receptor Activity Peptide Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Coactivator Activity Protein Binding Transcription Factor Binding Peroxisome Proliferator Activated Receptor Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway Cellular Response To Hormone Stimulus Response To Peptide	Negative Regulation Of Transcription From RNA Polymerase II Promoter Patterning Of Blood Vessels Transcription From RNA Polymerase II Promoter Inflammatory Response Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To UV Cellular Respiration Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Synaptic Plasticity Smooth Muscle Cell Differentiation Muscle Cell Development Cellular Response To Lithium Ion Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Height ( 20881960 23563607)
Protein-Protein Interactions		3 interactors: CEBPE NFATC4 TFAP2C	11 interactors: CCNG1 CREBBP GATA4 GPR22 JUP MAPK14 MAPK8 MAPK9 NR1I2 YWHAQ YWHAZ
Entrez ID		2845	4776
HPRD ID		03552	09096
Ensembl ID		ENSG00000172209	ENSG00000100968
Uniprot IDs		A4D0R8 B3KV13 Q3KNS9 Q99680	Q14934
PDB IDs			2YRP
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Branching Morphogenesis Of An Epithelial Tube Dichotomous Subdivision Of Terminal Units Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Morphogenesis Of A Branching Epithelium Positive Regulation Of Cellular Biosynthetic Process Morphogenesis Of A Branching Structure Regulation Of Transcription From RNA Polymerase II Promoter Epithelial Tube Morphogenesis Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Germ-line Stem Cell Maintenance Branch Elongation Involved In Mammary Gland Duct Branching Transcription, DNA-templated Tube Morphogenesis RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Keratinocyte Development Morphogenesis Of An Epithelium Sebaceous Gland Development Cellular Response To Lithium Ion Organ Development Tissue Morphogenesis Forebrain Neuron Fate Commitment Macrophage Differentiation RNA Metabolic Process Tube Development Mammary Gland Epithelial Cell Proliferation Cytokine Biosynthetic Process Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Trophectodermal Cell Differentiation Branch Elongation Of An Epithelium Cellular Macromolecule Biosynthetic Process Response To Lithium Ion Cytokine Metabolic Process Macromolecule Biosynthetic Process Axis Elongation Blastocyst Formation System Development Anatomical Structure Formation Involved In Morphogenesis Patterning Of Blood Vessels Regulation Of Transcription, DNA-templated Epithelium Development Negative Regulation Of Transcription, DNA-templated Branching Involved In Mammary Gland Duct Morphogenesis	Positive Regulation Of Intracellular Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Transport Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Stimulus Regulation Of Intracellular Transport JUN Phosphorylation Positive Regulation Of Apoptotic Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Response To Mechanical Stimulus Response To Organic Substance Positive Regulation Of Mitochondrion Organization Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Signal Transduction Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Response To Abiotic Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Organic Substance Signaling Cell Communication Toll-like Receptor 4 Signaling Pathway Regulation Of Establishment Of Protein Localization Response To Stimulus Regulation Of Signaling Regulation Of Mitochondrion Organization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Protein Localization Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Response To Organonitrogen Compound Response To Lipid Positive Regulation Of Gene Expression Pattern Recognition Receptor Signaling Pathway Cellular Response To Lipid Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin
Tagcloud ?		asymmetry cilia ciliogenesis details foxj1a gpcr gpcrs knock kupffer kv lefty1 lefty2 looping lpm lr master mesodermal morpholino organelles orphan patterning pitx2a player protrude randomization rfx2 southpaw tem vesicle	100mg 1beta 200mg 3mg aps astragalus colitis dai dexamethasone dexm elisa ethanol experimental expressions forty hapten herb ip macroscopic medicinal membranaceus microscopic polysaccharides receiving saline scores tnbs tnf vehicle
Tagcloud (Difference) ?		asymmetry cilia ciliogenesis details foxj1a gpcr gpcrs knock kupffer kv lefty1 lefty2 looping lpm lr master mesodermal morpholino organelles orphan patterning pitx2a player protrude randomization rfx2 southpaw tem vesicle	100mg 1beta 200mg 3mg aps astragalus colitis dai dexamethasone dexm elisa ethanol experimental expressions forty hapten herb ip macroscopic medicinal membranaceus microscopic polysaccharides receiving saline scores tnbs tnf vehicle
Tagcloud (Intersection) ?